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Titolo:
GASTROINTESTINAL INVOLVEMENT IN PROGRESSI V-SYSTEMIC SCLEROSIS [PSS]
Autore:
FOLWACZNY C; ROTHFUSS U; RIEPL RL; LEHNERT RL; BLOCHING H; MEURER M; KARBACH U;
Indirizzi:
UNIV MUNICH,KLINIKUM INNENSTADT,MED KLIN,ZIEMSSENSTR 1 D-80336 MUNICHGERMANY UNIV MUNICH,KLINIKUM INNENSTADT,DERMATOL KLIN MUNICH GERMANY RHEUMAKLIN BAD WURZACH OBERAMMERGAU GERMANY
Titolo Testata:
Zeitschrift fur Gastroenterologie
fascicolo: 11, volume: 33, anno: 1995,
pagine: 654 - 661
SICI:
0044-2771(1995)33:11<654:GIIPVS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
GER
Soggetto:
COLONIC TRANSIT; SMALL-INTESTINE; MOTOR-ACTIVITY; SCLERODERMA; ESOPHAGEAL; PATHOGENESIS; DYSFUNCTION; MANIFESTATIONS; RESPONSES; MOTILITY;
Keywords:
PROGRESSIVE-SYSTEMIC SCLEROSIS; INTESTINAL TRANSIT DISTURBANCES; CHOLYLGLYCINE; GASTRIN; MOTILIN; CHOLECYSTOKININ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
C. Folwaczny et al., "GASTROINTESTINAL INVOLVEMENT IN PROGRESSI V-SYSTEMIC SCLEROSIS [PSS]", Zeitschrift fur Gastroenterologie, 33(11), 1995, pp. 654-661

Abstract

The complained gastrointestinal symptoms in PSS are probably caused by several complex disturbances like intestinal transit disturbances (ITD), bacterial overgrowth of the small intestine caused malabsorption of bile acids and altered kinetics of intestinal hormones. 25 patientswith PSS and eleven healthy controls were tested for the existence ofITD by use of the metal-detector test (MDT). Twelve patients were also tested for a malabsorption of primary bile acids by radioimmunological measurement of cholylglycine serumlevels before and after a meal. In addition serumconcentrations of gastrin (nine patients) and plasmaconcentrations of cholecystokinin (CCK) (eight patients) and motilin (eleven patients) were measured by radioimmunoassay pre- and postprandial. Interdigestive gastric emptying was accelerated in patients with PSS(53 +/- 3 min. vs. 73 +/- 7 min.; p < 0.01). Small intestinal transittimes were similar in both groups (115 +/- 17 min. vs. 121 +/- 13 min.). Colonic transit in patients with PSS was significantly prolonged (63 +/- 6 h vs. 39 +/- 5 h; p < 0.05). There were no significant differences between the two groups concerning the pre- and postprandial levels of cholylglycin. Basic and postprandial levels of gastrin, CCK and motilin were higher in the PSS group. In contrast to scintigraphic studies using semisolid meals gastric emptying of the copper pellet in PSS was accelerated. A general malabsorption of primary bile acids was not found. Prolonged colonic transit times correlate well with frequently complained obstipation. Gastric hypacidity could be the reason of elevated gastrin levels. The high motilin-levels in PSS could be due toa lack of the feed-back inhibition as a result of diminished phase-ill activity of the interdigestive migrating motor complex. The elevation of CCK-levels could reflect compensation of neurogenic or myogenic disturbances of gallbladder contraction.

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Documento generato il 29/11/20 alle ore 02:08:12