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Titolo:
MICROSATELLITE INSTABILITY AND A TGF-BETA RECEPTOR - CLUES TO A GROWTH-CONTROL PATHWAY
Autore:
BENSON JR; WELLS K;
Indirizzi:
INST CANC RES,ACAD SURG SECT,HARTWELL LAB,FULHAM RD LONDON SW3 6JJ ENGLAND ROYAL MARSDEN HOSP LONDON SW3 6JJ ENGLAND
Titolo Testata:
BioEssays
fascicolo: 12, volume: 17, anno: 1995,
pagine: 1009 - 1012
SICI:
0265-9247(1995)17:12<1009:MIAATR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-WEIGHT COMPLEX; BREAST-CANCER; INHIBITORY RESPONSES; HUMAN-PLATELETS; CELL-LINES; REGULATOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Benson e K. Wells, "MICROSATELLITE INSTABILITY AND A TGF-BETA RECEPTOR - CLUES TO A GROWTH-CONTROL PATHWAY", BioEssays, 17(12), 1995, pp. 1009-1012

Abstract

Defects of growth inhibitory pathways have an important role in disorders of cell growth and differentiation. The discovery of a mutation in one of the principle components of the transforming growth factor beta (TGF beta) receptor system which is linked to a DNA repair defect(1) represents one possible mechanism of escape from negative regulatoryinfluences acting upon cells. TGF beta is a pre-eminent negative growth factor and this article discusses (1) the role of TGF beta in maintaining epithelial homeostasis; (2) how breakdown of inhibitory pathways can promote neoplastic development; (3) the significance of a receptor defect in a negative signalling pathway; and (4) the potential therapeutic sequelae resulting from restoration of cellular responsivenessto IGF beta.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 10:14:18