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Titolo:
EVALUATION OF THE PROTECTIVE EFFECT OF A NOVEL PROSTACYCLIN ANALOG ONMESENTERIC CIRCULATION FOLLOWING WARM ISCHEMIA
Autore:
MASHIMA S; SHIRAKAMI G; MITSUYOSHI A; NAKAGAMI M; MORIMOTO T; TERASAKI M; NAKAO K; YAMABE H; YAMAOKA Y; OZAWA K;
Indirizzi:
KYOTO UNIV,FAC MED,DEPT SURG 2,SAKYO KU,54 KAWARACHO KYOTO 606 JAPAN KYOTO UNIV,DEPT INTERNAL MED 2,SAKYO KU KYOTO 606 JAPAN KYOTO UNIV HOSP,ANAT PATHOL LAB KYOTO JAPAN SHIGA UNIV MED SCI SHIGA JAPAN
Titolo Testata:
European surgical research
fascicolo: 1, volume: 28, anno: 1996,
pagine: 14 - 25
SICI:
0014-312X(1996)28:1<14:EOTPEO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-AGGREGATION; ENDOTHELIAL-CELLS; RELAXING FACTOR; MUCOSAL LESION; NITRIC-OXIDE; RELEASE; PROSTAGLANDIN-I2; SUPEROXIDE; PRESERVATION; REPERFUSION;
Keywords:
INTESTINAL ISCHEMIA; MESENTERIC CIRCULATION; PROSTACYCLIN ANALOG; ENDOTHELIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
S. Mashima et al., "EVALUATION OF THE PROTECTIVE EFFECT OF A NOVEL PROSTACYCLIN ANALOG ONMESENTERIC CIRCULATION FOLLOWING WARM ISCHEMIA", European surgical research, 28(1), 1996, pp. 14-25

Abstract

The protective effect of a novel prostacyclin (PGI(2)) analog, OP-2507, on mesenteric circulation was investigated in a canine warm ischemia model. In 20 mongrel dogs, the entire portion of the intestine supplied by the superior mesenteric artery (SMA) and drained by the superior mesenteric vein (SMV) was completely isolated, maintaining the bloodand lymph vessels intact. Sixty or 120 min of complete warm ischemia (WI) of the intestine was induced by clamping SMA and SMV, followed byreperfusion for 120 min. Animals were divided into five groups (each n = 4): group 1, sham operation; group 2, 60 min WI; group 3, 120 min WI; group 4, 60 min WI with PGI(2) analog administration; group 5, 120min WI with PGI(2) analog administration. The analog was administeredat a rate of 6 mu g . kg(-1). h(-1) immediately after laparotomy until the end of the observation period. Mean arterial pressure, SMA bloodflow (SMABF), SMV pressure were monitored and total mesenteric vascular resistance (TMVR) was calculated. To evaluate the endothelial activation, endothelin, which is secreted from the endothelium under hypoxic stress, was assayed from blood samples of SMV. None of the animals showed significant changes in mean arterial pressure. In groups 2 and 3, SMABF decreased significantly to les than 60% of preoperative value (15 ml . kg(-1). min(-1)) and TMVR significantly increased from 8.1 and 7.3 mm Hg . ml(-1). kg . min before WI to 14.0 and 16.4 mm Hg . ml(-1). kg . min after 120 min reperfusion, respectively, resulting in delayed hypoperfusion. In contrast, in groups 4 and 5, SMABF increased toover 110% of preoperative level, while TMVR declined from 7.8 and 8.4mm Hg ml(-1) kg min before WI to 6.2 and 6.3 mm Hg ml(-1) kg min after 120 min reperfusion. After 60 min reperfusion, SMABF and TMVR showeda significant difference between the treated and nontreated groups. Only in group 3, high endothelin concentrations (over 20 pg/ml) were observed even after 120 min reperfusion. It was concluded that the PGI(2) analog was able to suppress the endothelial activation and the disturbance of mesenteric circulation caused by WI and reperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:37:08