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Titolo:
PRESSOR AND REFLEX SENSITIVITY IS ALTERED IN SPONTANEOUSLY HYPERTENSIVE RATS TREATED WITH ANGIOTENSIN-(1-7)
Autore:
BENTER IF; DIZ DI; FERRARIO CM;
Indirizzi:
SO COLL OPT,DIV BIOMED SCI,1245 MADISON AVE MEMPHIS TN 38104 WAKE FOREST UNIV,BOWMAN GRAY SCH MED,CTR HYPERTENS WINSTON SALEM NC 00000
Titolo Testata:
Hypertension
fascicolo: 6, volume: 26, anno: 1995,
parte:, 2
pagine: 1138 - 1144
SICI:
0194-911X(1995)26:6<1138:PARSIA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME-INHIBITOR; PROTEIN-KINASE-C; ARTERIAL BARORECEPTORS; RESISTANCE VESSELS; NOREPINEPHRINE; PROSTAGLANDINS; CONTRACTION; ACTIVATION; REACTIVITY;
Keywords:
PROSTAGLANDINS; NITRIC OXIDE; BLOOD PRESSURE; ANGIOTENSIN II; BAROREFLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
I.F. Benter et al., "PRESSOR AND REFLEX SENSITIVITY IS ALTERED IN SPONTANEOUSLY HYPERTENSIVE RATS TREATED WITH ANGIOTENSIN-(1-7)", Hypertension, 26(6), 1995, pp. 1138-1144

Abstract

We have suggested that angiotensin-(1-7) [Ang(1-7)] may oppose the presser activity of angiotensin II (Ang II). This hypothesis was supported by the fact that long-term intravenous infusion of Ang-(1-7) transiently lowers blood pressure in spontaneously hypertensive rats (SHR). We now investigated whether the presser sensitivity to bolus injections of either phenylephrine (PE) or Ang II was altered on day 12 of an Ang-(1-7) infusion when blood pressure in the SHR had returned to hypertensive levels. SHR (n=10) and WKY rats (n=8) were given Ang-(1-7) intravenously via osmotic minipumps at a dose of 24 mu g/kg per hour for 2 weeks. On day 12 of the infusion, mean arterial pressure and heart rate in halothane-anesthetized rats were similar in Ang-(1-7)-treated SHR (142+/-6 mm Hg; 388+/-9 beats per minute) and those infused with vehicle (146+/-5 mm Hg; 392+/-13 beats per minute). Presser responsiveness to PE in Ang-(1-7)-treated SHR was 22% less at a dose of 10 mu g, while presser responses to Ang II decreased by 20% and 25% at doses of 0.05 and 0.1 mu g, respectively, compared with the vehicle-treated SHR(P<.O5). There were no effects of the Ang-(1-7) infusion on presser responses to Ang II or PE in WKY rats. In the SHR infused with Ang-(1-7), there was a 35% improvement in sensitivity of the reflex control ofheart rate to levels not different from those in the untreated WKY rats (slope of the change in pulse interval versus the change in pressure increased from 0.34+/-0.03 to 0.46+/-0.01 ms/mm Hg). These data suggest that Ang-(1-7) may selectively activate antihypertensive mechanisms at the level of the vascular wall or the baroreflex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:08:33