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Titolo:
GALANTIDE DISTINGUISHES PUTATIVE SUBTYPES OF GALANIN RECEPTORS IN MUDPUPPY PARASYMPATHETIC NEURONS
Autore:
MULVANEY JM; MERRIAM LA; PARSONS RL;
Indirizzi:
UNIV VERMONT,COLL MED,DEPT ANAT & NEUROBIOL BURLINGTON VT 05405 UNIV VERMONT,COLL MED,DEPT ANAT & NEUROBIOL BURLINGTON VT 05405
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 287, anno: 1995,
pagine: 97 - 100
SICI:
0014-2999(1995)287:1<97:GDPSOG>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIDE; ANTAGONISTS; ANALOGS;
Keywords:
GALANTIDE; GALANIN; PARASYMPATHETIC NEURON; K+ CONDUCTANCE; CA2+ CONDUCTANCE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Mulvaney et al., "GALANTIDE DISTINGUISHES PUTATIVE SUBTYPES OF GALANIN RECEPTORS IN MUDPUPPY PARASYMPATHETIC NEURONS", European journal of pharmacology, 287(1), 1995, pp. 97-100

Abstract

The effect of the chimeric ligand galantide on the galanin-induced activation of membrane K+ conductance and inhibition of voltage-dependent Ca2+ conductance has been studied using voltage-clamped dissociated mudpuppy parasympathetic neurons. Galantide did not activate the K+ conductance but produced a concentration-dependent antagonism (IC50=4 nM) of the galanin-induced increase in K+ conductance. Galantide acted like galanin and inhibited the voltage-dependent Ba2+ current (I-Ba). The inhibition of I-Ba also was concentration dependent (IC50=16 nM) and the maximum inhibition produced by galantide was approximately 40%. We also demonstrate that the galanin-(1-16) fragment increased the membrane K+ conductance and decreased I-Ba, suggesting that the NH2 portion of the galanin molecule is sufficient to mediate both actions. One interpretation of these observations is that different galanin receptors mediate the different effects of galanin on the mudpuppy parasympathetic neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 13:47:51