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Titolo:
NITRIC-OXIDE SYNTHASE-IMMUNOREACTIVE, ADRENERGIC, CHOLINERGIC, AND PEPTIDERGIC NERVES OF THE FEMALE RAT URINARY-TRACT - A COMPARATIVE-STUDY
Autore:
ALM P; ZYGMUNT PKE; ISELIN C; LARSSON B; UVELIUS B; WERNER S; ANDERSSON KE;
Indirizzi:
UNIV LUND HOSP,DEPT PATHOL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT CLIN PHARMACOL S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT UROL S-22185 LUND SWEDEN HOP CANTONAL UNIV GENEVA GENEVA SWITZERLAND
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 1-2, volume: 56, anno: 1995,
pagine: 105 - 114
SICI:
0165-1838(1995)56:1-2<105:NSACAP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; NEURONAL NADPH DIAPHORASE; BLADDER; LOCALIZATION; RELAXATION; INNERVATION; AFFERENT; FIBERS; SHEEP; IMMUNOHISTOCHEMISTRY;
Keywords:
URINARY TRACT; NERVE DISTRIBUTION; SMOOTH MUSCLE; NITRIC OXIDE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
P. Alm et al., "NITRIC-OXIDE SYNTHASE-IMMUNOREACTIVE, ADRENERGIC, CHOLINERGIC, AND PEPTIDERGIC NERVES OF THE FEMALE RAT URINARY-TRACT - A COMPARATIVE-STUDY", Journal of the autonomic nervous system, 56(1-2), 1995, pp. 105-114

Abstract

The distribution and frequency of NO synthase (NOS)-immunoreactive (IR) nerves in relation to the general autonomic innervation, adrenergic, cholinergic and some peptidergic nerves, were investigated in the female rat urinary tract. NOS nerves were very frequent in the smooth musculature of the urethra together with cholinergic, adrenergic and neuropeptide Y (NPY)-IR nerves, whereas vasoactive intestinal peptide (VIP)-lR and calcitonin-gene-related peptide (CGRP)-IR nerves were much less abundant. NOS-IR, CGRP-IR and cholinergic nerves were also frequent in the longitudinal smooth musculature of the distal ureters and theureteral orifices into the bladder, where no adrenergic, NPY-IR and VIP-IR nerves were found. In contrast, in the detrusor NOS-IR nerves were scarce. Bilateral pelvic ganglionectomy very pronouncedly decreasedthe number of any of the populations of nerves studied, whereas bilateral pelvic decentralization selectively reduced the number of CGRP-IRnerves in all structures and locations. Outflow obstruction very overtly reduced the number of NOS-LR nerves in parallel with the general autonomic innervation. Thus, in the rat female urinary tract, NOS-containing nerves particularly occur in regions with sphincteric functions such as urethra and ureteric orifices. In these regions NO may exert atransmitter role, both directly or by interaction with other transmitters/modulators.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:23:33