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Titolo:
METHACHOLINE CHALLENGE DOES NOT AFFECT BRONCHOALVEOLAR FLUID CELL NUMBER AND MANY INDEXES OF CELL-FUNCTION IN ASTHMA
Autore:
KRAFT M; BETTINGER CM; WENZEL SE; IRVIN CG; ACKERMAN SJ; MARTIN RJ;
Indirizzi:
NATL JEWISH CTR IMMUNOL & RESP MED,DEPT MED,ROOM J107,1400 JACKSON STDENVER CO 80206 UNIV COLORADO,HLTH SCI CTR,DIV PULM & CRIT CARE DENVER CO 00000 BETH ISRAEL HOSP,DIV INFECT DIS BOSTON MA 02215 HARVARD UNIV,SCH MED BOSTON MA 00000
Titolo Testata:
The European respiratory journal
fascicolo: 11, volume: 8, anno: 1995,
pagine: 1966 - 1971
SICI:
0903-1936(1995)8:11<1966:MCDNAB>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEYDEN CRYSTAL PROTEIN; RADIOIMMUNOASSAY; RESPONSIVENESS; MEDIATORS; LAVAGE;
Keywords:
BRONCHOALVEOLAR LAVAGE; BRONCHOSCOPY; METHACHOLINE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M. Kraft et al., "METHACHOLINE CHALLENGE DOES NOT AFFECT BRONCHOALVEOLAR FLUID CELL NUMBER AND MANY INDEXES OF CELL-FUNCTION IN ASTHMA", The European respiratory journal, 8(11), 1995, pp. 1966-1971

Abstract

Methacholine (MCh) challenge testing is often incorporated into clinical studies prior to performing bronchoscopy as a measure of bronchial hyperresponsiveness (BHR). However, the effect of methacholine on many aspects of bronchoalveolar lavage (BAL) fluid cell count and function have not been fully evaluated,Ten patients with asthma, maintained on inhaled beta(2)-agonists, were studied, Each subject underwent two bronchoscopies in a random order, one preceded by methacholine challenge within 30 min of the BAL, The investigators were blinded to the regimen, Several markers of BAL fluid cell number and function were studied: cell count and differential, histamine, eosinophil products, including eosinophil cationic protein and Charcot-Leyden crystal protein, macrophage production of thromboxane B-2 and leukotriene B-4, neutrophil lysozyme and lactoferrin, lymphocyte typing and activation markers measured via flow cytometry,No significant differences were noted in any of these markers of cell number or function which could be ascribed to methacholine challenge, Thus, methacholine challenge does not appear to affect these markers of fell number and function, These findings indicate that a methacholine challenge can be used as a measure of bronchial hyperresponsiveness within 30 min prior to bronchoscopy withoutaltering bronchoalveolar lavage fluid characteristics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:18:12