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Titolo:
POSTISCHEMIC ADMINISTRATION OF HU-211, A NOVEL NONCOMPETITIVE NMDA ANTAGONIST, PROTECTS AGAINST BLOOD-BRAIN-BARRIER DISRUPTION IN PHOTOCHEMICAL CORTICAL INFARCTION IN RATS - A QUANTITATIVE STUDY
Autore:
BELAYEV L; BUSTO R; WATSON BD; GINSBERG MD;
Indirizzi:
UNIV MIAMI,SCH MED,DEPT NEUROL D4-5,CEREBRAL VASC DIS RES CTR,POB 016960 MIAMI FL 33101 UNIV MIAMI,SCH MED,DEPT NEUROL D4-5,CEREBRAL VASC DIS RES CTR MIAMI FL 33101
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 702, anno: 1995,
pagine: 266 - 270
SICI:
0006-8993(1995)702:1-2<266:PAOHAN>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; INDUCED CEREBRAL INFARCTION; NEOCORTICAL INFARCTS; ARTERY OCCLUSION; EDEMA; PERMEABILITY; CONSEQUENCES; GERBIL; MODEL;
Keywords:
HU-211; PHOTOCHEMICAL CORTICAL INFARCTION; BLOOD-BRAIN BARRIER; EVANS BLUE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
L. Belayev et al., "POSTISCHEMIC ADMINISTRATION OF HU-211, A NOVEL NONCOMPETITIVE NMDA ANTAGONIST, PROTECTS AGAINST BLOOD-BRAIN-BARRIER DISRUPTION IN PHOTOCHEMICAL CORTICAL INFARCTION IN RATS - A QUANTITATIVE STUDY", Brain research, 702(1-2), 1995, pp. 266-270

Abstract

We examined the effect of HU-211, a synthetic non-psychotropic cannabinoid with non-competitive N-methyl-D-aspartate (NMDA) antagonist properties, on blood-brain barrier (BBB) integrity after photochemically induced cortical infarction. Evans blue dye was used as a BBB permeability indicator after unilateral thrombotic cortical infarction was produced photochemically by 560 nm light irradiation of the cortex in maleWistar rats receiving rose bengal intravenously. HU-211 was injected in a dose of 4 mg/kg i.v. 30 min after stroke. Fluorometric measurement of Evans blue was performed 24 h later in six brain regions. Treatment with HU-211 significantly decreased extravasation of dye into the area of infarct (405 +/- 19 vs. 539 +/- 33 mu g/g, mean +/- S.E.M.) as well as other sites of the affected hemisphere (866 +/- 68 vs. 1096 +/- 68 mu g/g) compared to the vehicle group. These data indicate that HU-211 is an effective drug in protecting against the effects of focal ischemia-induced BBB disruption in the rat and suggest that the drug may be an effective treatment against the ischemic cell death and BBB disruption that can occur clinically following a stroke or cardiac arrest.

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Documento generato il 31/10/20 alle ore 21:17:39