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Titolo:
SOURCES OF HUMAN HEMATOPOIETIC STEM-CELLS FOR TRANSPLANTATION - A REVIEW
Autore:
AMOS TAS; GORDON MY;
Indirizzi:
INST CANC RES,LEUKAEMIA RES FUND CTR,237 FULHAM RD LONDON SW3 6JB ENGLAND
Titolo Testata:
Cell transplantation
fascicolo: 6, volume: 4, anno: 1995,
pagine: 547 - 569
SICI:
0963-6897(1995)4:6<547:SOHHSF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; UMBILICAL-CORD BLOOD; COLONY-STIMULATING FACTOR; HUMAN-FETAL LIVER; VERSUS-HOST DISEASE; SEVERE COMBINED IMMUNODEFICIENCY; HUMAN PERIPHERAL-BLOOD; LONG-TERM CULTURE; CHRONIC MYELOGENOUS LEUKEMIA; NON-LYMPHOBLASTIC LEUKEMIA;
Keywords:
HEMATOPOIETIC STEM CELLS; BONE MARROW; UMBILICAL CORD BLOOD; FETAL LIVER; PERIPHERAL BLOOD PROGENITOR CELLS; STEM CELL EXPANSION; TRANSPLANTATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
256
Recensione:
Indirizzi per estratti:
Citazione:
T.A.S. Amos e M.Y. Gordon, "SOURCES OF HUMAN HEMATOPOIETIC STEM-CELLS FOR TRANSPLANTATION - A REVIEW", Cell transplantation, 4(6), 1995, pp. 547-569

Abstract

Transplantation of hematopoietic stem cells provides a means of replacing a defective hematopoietic system in patients with a wide range ofmalignant and nonmalignant disorders that affect the blood forming tissue. The same procedure has also allowed dose-escalation of standard chemotherapy and radiotherapy in the treatment of malignant disease ofnonhematological origin, Until recently, bone marrow has been the sole source of hematopoietic stem cells, but limitations of conventional bone marrow transplantation have stimulated a search for alternative sources and uses of stem cells, Fetal tissues (especially liver) are a recognized source of transplantable stem cells and offer the great advantage of reduced immunogenicity, potentially removing the problems oftissue type matching. Umbilical cord blood is also a rich source of stem cells and, although it contains alloreactive cells, it is readily available without special ethical constraints, Both fetal tissue and cord blood suffer the disadvantages of limited numbers of stem cells per donation, and there is much interest in the development of technologies for the safe and reliable expansion and/or pooling of stem and progenitor cells, The observation that small numbers of stem cells are found in the peripheral blood of adults has led to the exploitation of the blood as a further source of stem cells, The ability to mobilize these cells from the medullary compartment into the periphery by the useof chemotherapy and/or recombinant hematopoietic growth factors has enabled the collection of sufficient numbers of cells for transplantation purposes, All of these advances are increasing the options and the range of choices available to clinicians and patients in the arena of hematopoietic stem cell transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 10:50:23