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Titolo:
PREFERRED USAGE OF SPECIFIC IMMUNOGLOBULIN GENE SEGMENTS IN CHRONIC LYMPHOCYTIC-LEUKEMIA CELLS OF 3 HLA-IDENTICAL SISTERS
Autore:
HAKIM I; AMARIGLIO N; BROKSIMONI F; BERKOWITZ M; ROSNER E; KNELLER A; HULU N; RAMOT B; BENBASSAT I; SILVERMAN GJ; RECHAVI G;
Indirizzi:
TEL AVIV UNIV,CHAIM SHEBA MED CTR,SACKLER SCH MED,INST HAEMATOL IL-56261 TEL HASHOMER ISRAEL TEL AVIV UNIV,CHAIM SHEBA MED CTR,SACKLER SCH MED,INST HAEMATOL IL-56261 TEL HASHOMER ISRAEL UNIV CALIF SAN DIEGO SAN DIEGO CA 92103
Titolo Testata:
British Journal of Haematology
fascicolo: 4, volume: 91, anno: 1995,
pagine: 915 - 917
SICI:
0007-1048(1995)91:4<915:PUOSIG>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKEMIA; EXPRESSION; FAMILIES;
Keywords:
IMMUNOGLOBULIN GENE SEGMENTS; CLL; HLA ANTIGEN;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
I. Hakim et al., "PREFERRED USAGE OF SPECIFIC IMMUNOGLOBULIN GENE SEGMENTS IN CHRONIC LYMPHOCYTIC-LEUKEMIA CELLS OF 3 HLA-IDENTICAL SISTERS", British Journal of Haematology, 91(4), 1995, pp. 915-917

Abstract

We report three family members, including a set of identical twins, who developed CD5 positive B-CLL. The patients are female Ashkenazi Jews sharing an identical HLA mal studies suggest a process of clonal evolution in one of the phenotype. Two of the HLA loci (B35 and Cw4) weretwins. common with those already described as being shared by Ashkenazi Jews with an increased incidence of CLL, The rearranged immunoglobulin genes of the malignant cells of all three patients were found to express genetically related V-H regions belonging to the V-H(3) subgroup, and chromosomal studies suggest a process of clonal evolution in one of the twins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 15:06:41