Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RENIN-LIKE IMMUNOREACTIVITY IN HUMAN PLACENTA AND FETAL MEMBRANES
Autore:
HANSSENS M; VERCRUYSSE L; VERBIST L; PIJNENBORG R; KEIRSE MJNC; VANASSCHE FA;
Indirizzi:
CATHOLIC UNIV LEUVEN,DEPT OBSTET & GYNAECOL,HERESTR 49 B-3000 LOUVAINBELGIUM LEIDEN UNIV,DEPT OBSTET GYNAECOL & REPROD MED 2300 RA LEIDEN NETHERLANDS
Titolo Testata:
HISTOCHEMISTRY AND CELL BIOLOGY
fascicolo: 6, volume: 104, anno: 1995,
pagine: 435 - 442
SICI:
0948-6143(1995)104:6<435:RIIHPA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY LACTOTROPH CELLS; FEMALE GENITAL-TRACT; INACTIVE RENIN; CATHEPSIN-D; MONOCLONAL-ANTIBODIES; ANGIOTENSINOGEN GENES; CONVERTING ENZYME; TERM PREGNANCY; HUMAN PRORENIN; TISSUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
M. Hanssens et al., "RENIN-LIKE IMMUNOREACTIVITY IN HUMAN PLACENTA AND FETAL MEMBRANES", HISTOCHEM C, 104(6), 1995, pp. 435-442

Abstract

Five antibodies that stained renin in the kidney were used to investigate the presence of renin in human placenta and fetal membranes. Despite a large number of experimental approaches to enhance penetration of the immunoglobulins, only two of them showed immunostaining in placenta and fetal membranes. Staining was found in placental syncytiotrophoblast, the amnionic epithelium overlying the placenta, and in glandular epithelial cells present in the decidua adhering to the fetal membranes. It was most consistent, however, in a small infiltrating cell type dispersed through the fetoplacental layers. The two antibodies thatrevealed immunostaining in all preparations showed high affinity cross-reactivity with cathepsin D. Among other, less plausible, explanations, this raises the possibility that the bulk of 'renin' found in placenta and fetal membranes is not identical to renal renin, but may be cathepsin D or a substance related to both cathepsin D and renin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:35:39