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Titolo:
HYPOXIA PRECEDES THE DEVELOPMENT OF EXPERIMENTAL PRERETINAL NEOVASCULARIZATION
Autore:
HANDA JT; BERKOWITZ BA; WILSON CA; ANDO N; SEN HA; JAFFE GJ;
Indirizzi:
UNIV TEXAS,SW MED CTR,DEPT OPHTHALMOL DALLAS TX 75235 UNIV TEXAS,SW MED CTR,DEPT OPHTHALMOL DALLAS TX 75235 DUKE EYE CTR DURHAM NC 00000 NIEHS RES TRIANGLE PK NC 27709
Titolo Testata:
Graefe's archive for clinical and experimental ophthalmology
fascicolo: 1, volume: 234, anno: 1996,
pagine: 43 - 46
SICI:
0721-832X(1996)234:1<43:HPTDOE>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLIFERATIVE DIABETIC-RETINOPATHY; OXYGEN-TENSION; F-19 NMR; RABBIT; VITREORETINOPATHY; ANGIOGENESIS; DEGENERATION; MACROPHAGES; EYE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
J.T. Handa et al., "HYPOXIA PRECEDES THE DEVELOPMENT OF EXPERIMENTAL PRERETINAL NEOVASCULARIZATION", Graefe's archive for clinical and experimental ophthalmology, 234(1), 1996, pp. 43-46

Abstract

Background: Although the mechanism of preretinal neovascular growth in the cell-injected rabbit eye model is not known, it has been proposed that the initial vasodilation and eventual development of neovascularization may be attributable to inflammatory mediators. However, an alternative explanation involving hypoxia has not been considered. The purpose of this study was to measure preretinal oxygen tension prior tothe development of preretinal neovascularization in the cell-injectedrabbit eye. Methods: In the rabbit, intravitreous injections of 250 000 homologous dermal fibroblasts were performed on one eye; the fellow(control) eye was injected with vehicle. Preretinal oxygen tension over the myelin wing was measured using F-19-NMR spectroscopy of a 30-mul droplet of perfluorocarbon previously injected into the preretinal vitreous. Results: Compared to control eyes, fibroblast-injected eyes showed a 1.7-fold decrease in preretinal oxygen tension from the firsttime studied (1 day after cell injection) through the development of visible neovascularization. Hypoxia occurred without coexisting ophthalmoscopic evidence of vascular occlusion or, on days 1 and 3 after cell injection, retinal detachment. Conclusion: This result demonstrates for the first time that preretinal hypoxia precedes the development ofpreretinal neovascularization in the fibroblast-injected rabbit eye.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:34:43