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Titolo:
MR-IMAGING OF HEAD AND NECK LESIONS USING HIGH-DOSE GADODIAMIDE INJECTION - A PHASE-III CLINICAL-TRIAL
Autore:
VOGL TJ; WESTERN A; MACK MG; KJAERSGAARD P; JUERGENS M; BALZER JO; FELIX R;
Indirizzi:
FREE UNIV BERLIN,RUDOLF VIRCHOW HOSP,DEPT RADIOL,AUGUSTENBURGER PL 1 D-13353 BERLIN GERMANY NYCOMED ARZNEIMITTEL GMBH,CLIN RES & DEV MUNICH GERMANY NYCOMED IMAGING AS,CLIN RES & DEV N-0401 OSLO NORWAY
Titolo Testata:
European radiology
fascicolo: 6, volume: 5, anno: 1995,
pagine: 609 - 614
SICI:
0938-7994(1995)5:6<609:MOHANL>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GADOPENTETATE DIMEGLUMINE; TUMORS; BRAIN; SPINE;
Keywords:
MAGNETIC RESONANCE; HEAD AND NECK; GADODIAMIDE INJECTION; CONTRAST MEDIUM; CONTRAST ENHANCEMENT; CLINICAL TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Vogl et al., "MR-IMAGING OF HEAD AND NECK LESIONS USING HIGH-DOSE GADODIAMIDE INJECTION - A PHASE-III CLINICAL-TRIAL", European radiology, 5(6), 1995, pp. 609-614

Abstract

In order to evaluate the safety and efficacy of a high-dose gadodiamide injection a phase-III trial was conducted using a dose of 0.3 mmol Gd/kg bw in patients with known or suspected tumors in the head and neck region. A total of 90 in- and outpatients referred to MR examination for tumor in the head and neck area were included. Precontrast images consisted of T-1- and T-2-weighted sequences. A FATSAT sequence was also applied. After i.v. contrast administration T-1-weighted scans were obtained. Efficacy was evaluated by means of a comparisons of the pre- and postcontrast images. Postcontrast images gave more diagnostic information compared with precontrast images, which facilitated diagnosis in all patients. In 8 patients T-1-weighted post contrast images revealed abnormal structure not seen on precontrast images and no lesion was obscured by the contrast medium. Gadodiamide injection at a doseof 0.3 mmol GD/kg bw was judged as safe and effective for the examination of tumors in the head and neck region. Use of the contrast mediumincreased the diagnostic information in the images and increased the confidence in making the diagnosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:04:52