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Titolo:
DIASPIRIN CROSS-LINKED HEMOGLOBIN DOES NOT INCREASE BRAIN OXYGEN-CONSUMPTION DURING HYPOTHERMIC CARDIOPULMONARY BYPASS IN RABBITS
Autore:
HINDMAN BJ; DEXTER F; CUTKOMP J; SMITH T;
Titolo Testata:
Anesthesiology
fascicolo: 6, volume: 83, anno: 1995,
pagine: 1302 - 1311
SICI:
0003-3022(1995)83:6<1302:DCHDNI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPEN-HEART SURGERY; BLOOD-CELL DEFORMABILITY; FOCAL CEREBRAL-ISCHEMIA; CORONARY-ARTERY BYPASS; FLOW MEASUREMENTS; RATS; PENTOXIFYLLINE; FILTERABILITY; HEMODILUTION; TEMPERATURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
B.J. Hindman et al., "DIASPIRIN CROSS-LINKED HEMOGLOBIN DOES NOT INCREASE BRAIN OXYGEN-CONSUMPTION DURING HYPOTHERMIC CARDIOPULMONARY BYPASS IN RABBITS", Anesthesiology, 83(6), 1995, pp. 1302-1311

Abstract

Background: Decreased erythrocyte deformability due to cardiopulmonary bypass (CPB) and/or hypothermia, may result in brain capillary beds that have decreased erythrocyte transit, resulting in a generalized impairment of brain oxygenation during CPB. Because brain capillary plasma now continues even when erythrocyte now is absent, the authors' hypothesized augmentation of plasma oxygen content with a non-erythrocyte-associated oxygen transport molecule would increase brain oxygen uptake during hypothermic CPB. Methods: Anesthetized New Zealand white rabbits, maintained on CPB at 27 degrees C, were randomized to one of three groups. In group 1 (n = 13), plasma oxygen content was increased byadministration of alpha-alpha diaspirin cross-linked hemoglobin. In this group, pretreatment with 0.5 mg/kg verapamil was necessary to prevent hypertension. In group 2 (n = 13), alpha-alpha diaspirin cross-linked hemoglobin was not administered, but verapamil was given as before(control). In group 3 (n = 13), neither alpha-alpha diaspirin cross-linked hemoglobin nor verapamil was administered (control). At 60 min of CPB, cerebral blood flow (microspheres) and cerebral metabolic rate for oxygen (Fick) were determined. Results: Systemic physiologic variables did not differ among groups. Although total arterial oxygen content was equivalent in all groups (similar to 12.1 ml O-2/dl), the alpha-alpha diaspirin cross-linked hemoglobin group had a much greater proportion of the total arterial oxygen content present in a non-erythrocyte-associated form, 29 +/- 5% versus 6 +/- 2% and 5 +/- 3%, in groups 2 and 3, respectively. Nevertheless, neither cerebral blood flow (similar to 34 ml . 100 g(-1) . min(-1)) nor cerebral metabolic rate for oxygen (similar to 1.2 ml O-2 . 100g(-1) . min(-1)) differed among groups. Conclusions: Because oxygen was equally available to the brain in all groups, independent of whether oxygen was associated with erythrocytes or not, it was concluded that erythrocyte/capillary interactions do not limit oxygen transfer from blood to brain during moderately hypothermic CPB. The hypertensive response to alpha-alpha diaspirin cross-linked hemoglobin during CPB is probably a result of nitric oxide scavenging.

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Documento generato il 12/07/20 alle ore 06:28:38