Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
COMPARATIVE GENOMIC IN-SITU HYBRIDIZATION OF COLON CARCINOMAS WITH REPLICATION ERROR
Autore:
SCHLEGEL J; STUMM G; SCHERTHAN H; BOCKER T; ZIRNGIBL H; RUSCHOFF J; HOFSTADTER F;
Indirizzi:
UNIV MARBURG KLIN,NEUROPATHOL ABT,BALDINGERSTR D-35033 MARBURG GERMANY UNIV REGENSBURG,INST PATHOL W-8400 REGENSBURG GERMANY UNIV REGENSBURG,CHIRURG KLIN W-8400 REGENSBURG GERMANY UNIV KAISERSLAUTERN,HUMAN BIOL & HUMAN GENET ABT W-6750 KAISERSLAUTERN GERMANY
Titolo Testata:
Cancer research
fascicolo: 24, volume: 55, anno: 1995,
pagine: 6002 - 6005
SICI:
0008-5472(1995)55:24<6002:CGIHOC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLORECTAL-CANCER; INSTABILITY; MUTATIONS; SEQUENCES; HOMOLOG;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
J. Schlegel et al., "COMPARATIVE GENOMIC IN-SITU HYBRIDIZATION OF COLON CARCINOMAS WITH REPLICATION ERROR", Cancer research, 55(24), 1995, pp. 6002-6005

Abstract

The aim of the present study was to detect complex; genetic alterations in colorectal carcinomas with and without microsatellite instability (MIN) by comparative genomic in situ hybridization, MIN due to replication errors is the hallmark of hereditary nonpolyposis colon cancer,None of 6 MIN-positive tumors showed amplifications, and only 2 tumors displayed deletions of one chromosomal segment each, In contrast, different gains and losses were observed in 11 of 12 MIN-negative carcinomas, The most frequent gains affected chromosomes 7, 13, and 20q, whereas deletions were observed on chromosomes 17, 18, and 9p, These results demonstrate different mechanisms of genetic instability in subgroups of colorectal carcinomas and may, therefore, support the hypothesisof different etiologies in tumors with and without MIN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 20:30:18