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Titolo:
REPEATED MATERNAL SEPARATION OF PREWEANLING RATS ATTENUATES BEHAVIORAL-RESPONSES TO PRIMARY AND CONDITIONED INCENTIVES IN ADULTHOOD
Autore:
MATTHEWS K; WILKINSON LS; ROBBINS TW;
Indirizzi:
UNIV CAMBRIDGE,DEPT EXPTL PSYCHOL,DOWNING ST CAMBRIDGE CB2 3EB ENGLAND
Titolo Testata:
Physiology & behavior
fascicolo: 1, volume: 59, anno: 1996,
pagine: 99 - 107
SICI:
0031-9384(1996)59:1<99:RMSOPR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM GROWTH-HORMONE; EXCITOTOXIC LESIONS; LOCOMOTOR-ACTIVITY; NUCLEUS-ACCUMBENS; SOCIAL-ISOLATION; INFANT RAT; DEPRIVATION; DOPAMINE; AMPHETAMINE; REWARD;
Keywords:
MATERNAL SEPARATION; DEVELOPMENT; REWARD; CONDITIONED INCENTIVES; NOVELTY; CONDITIONED LOCOMOTOR ACTIVITY; SUCCESSIVE NEGATIVE CONTRAST; SUCCESSIVE POSITIVE CONTRAST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
K. Matthews et al., "REPEATED MATERNAL SEPARATION OF PREWEANLING RATS ATTENUATES BEHAVIORAL-RESPONSES TO PRIMARY AND CONDITIONED INCENTIVES IN ADULTHOOD", Physiology & behavior, 59(1), 1996, pp. 99-107

Abstract

Early social experience has profound effects on a wide spectrum of behaviors and neurochemical correlates in the rat. Repeated separation of rat pups from their dam during the early neonatal period causes acute perturbation of neuroendocrine and physiological status. The chronicsequelae of repeated separations have not been studied as extensivelyas the acute responses. Altered social experience at a later developmental stage, postweaning isolation rearing, is known to induce enduring changes in the behavioral responses to reward and reward-related stimuli in maturity. We have evaluated the influence of repeated early maternal separation on the responses to both primary and conditioned incentives in mature rats. Separated animals showed enhanced weight gain,a blunted locomotor response to a novel environment and a blunting ofthe response to both negative and positive contrast effects. Female separated animals, but not males, exhibited a profound attenuation of the acquisition of a conditioned anticipatory locomotor response to thepresentation of food. These data are discussed with respect to the putative involvement of ventral striatal dopamine systems in reward mechanisms and the potential utility of early maternal separation as an animal model of depression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 16:59:16