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Titolo:
EFFECTS OF PROPOFOL ON VASCULAR SMOOTH-MUSCLE FUNCTION IN ISOLATED RAT AORTA
Autore:
MIMAROGLU C; UTKAN T; KAYA T; KAFALI H; SARIOGLU Y;
Indirizzi:
CUMHURIYET UNIV,FAK TIP,DEPT PHARMACOL SIVAS TURKEY CUMHURIYET UNIV,FAK TIP,DEPT PHARMACOL SIVAS TURKEY CUMHURIYET UNIV,DEPT ANESTHESIOL SIVAS TURKEY
Titolo Testata:
Methods and findings in experimental and clinical pharmacology
fascicolo: 4, volume: 16, anno: 1994,
pagine: 257 - 261
SICI:
0379-0355(1994)16:4<257:EOPOVS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RELAXATION; ARTERIES; DOG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
12
Recensione:
Indirizzi per estratti:
Citazione:
C. Mimaroglu et al., "EFFECTS OF PROPOFOL ON VASCULAR SMOOTH-MUSCLE FUNCTION IN ISOLATED RAT AORTA", Methods and findings in experimental and clinical pharmacology, 16(4), 1994, pp. 257-261

Abstract

This study was undertaken to determine the direct actions of propofol, and whether propofol exerts any action on basal endothelium-derived relaxing factor release and vasodilator effect of acetylcholine on phenylephrine-induced contractile responses in isolated rat aortic rings. This compound is known to produce a fall in blood pressure in man andanimals, and it has been suggested that the hypotension may result from a direct vasodilator action on the veins and arterioles. In this study propofol did not induce any contractile response in aortic rings at various concentrations (10(-8)-10(-4) M). Propofol did not significantly alter phenylephrine-induced contractions at lower concentrations (10(-8)-10(-6)M) but at higher concentrations (10(-5)-10(-4)M) the depression caused by propofol was significant in both endothelium-intact and -denuded rings. Pretreatment of the endothelium-intact rings with propofol (10(-6) and 10(-5) M) produced a reduction in the relaxant effect of acetylcholine. The results obtained in this study demonstrate that clinically relevant concentrations of propofol (10(-6)M or less) have no direct vasodilator effects and that it reduces endothelium-dependent relaxation to acetylcholine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:11:11