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Titolo:
COMBINATIONS OF POTASSIUM, CALCIUM, AND MAGNESIUM SUPPLEMENTS IN HYPERTENSION
Autore:
SACKS FM; BROWN LE; APPEL L; BORHANI NO; EVANS D; WHELTON P;
Indirizzi:
HARVARD UNIV,SCH PUBL HLTH,DEPT NUTR,665 HUNTINGTON AVE BOSTON MA 02115 HARVARD UNIV,SCH MED,CHANNING LAB,DEPT MED BOSTON MA 02115 BRIGHAM & WOMENS HOSP BOSTON MA 02115 JOHNS HOPKINS MED INST,WELSH CTR PREVENT EPIDEMIOL & CLIN RES BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT MED BALTIMORE MD 21205 JOHNS HOPKINS MED INST,DEPT EPIDEMIOL BALTIMORE MD 21205 UNIV NEVADA,DEPT FAMILY & COMMUNITY MED RENO NV 89557
Titolo Testata:
Hypertension
fascicolo: 6, volume: 26, anno: 1995,
parte:, 1
pagine: 950 - 956
SICI:
0194-911X(1995)26:6<950:COPCAM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMBULATORY BLOOD-PRESSURE; DOUBLE-BLIND; NUTRITIONAL FACTORS; CONTROLLED TRIAL; DIETARY CALCIUM; ORAL MAGNESIUM; SODIUM; MILD; RESPONSIVENESS; POPULATIONS;
Keywords:
DIET; BLOOD PRESSURE; POTASSIUM; MAGNESIUM; CALCIUM; FOOD, FORTIFIED;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
F.M. Sacks et al., "COMBINATIONS OF POTASSIUM, CALCIUM, AND MAGNESIUM SUPPLEMENTS IN HYPERTENSION", Hypertension, 26(6), 1995, pp. 950-956

Abstract

Dietary intakes of potassium, calcium, and magnesium have each been reported to lower blood pressure, but the extent of blood pressure reduction in epidemiological studies and clinical trials has tended to be small and inconsistent. We hypothesized that combinations of these mineral supplements would lower blood pressure and that the reductions would be greater than that usually reported in studies of each cation alone. One hundred twenty-five patients (82 men and 43 women) with untreated mild or borderline hypertension were randomly assigned to daily treatment with one of the following four regimens: 60 mmol potassium and 25 mmol (1000 mg) calcium, 60 mmol potassium and 15 mmol (360 mg) magnesium, calcium and magnesium, or placebo. Standardized clinic blood pressure measurements were obtained on 3 days at baseline and after 3 and 6 months of treatment. At baseline, systolic and diastolic blood pressures (mean+/-SD) were 139+/-12 and 90+/-4 mm Hg, respectively, anddietary intakes of potassium, calcium, and magnesium were 77+/-32, 19/-13, and 12+/-52 mmol/d, respectively. The mean differences (with 95% confidence intervals) of the changes in systolic and diastolic bloodpressures between the treatment and placebo groups were not significant: -0.7 (-4.3 to +2.9) and -0.4 (-2.9 to +2.1) for potassium and calcium, -1.3 (-4.4 to +1.8) and 0.4 (-2.5 to +3.3) for potassium and magnesium, and +2.1 (-1.8 to +6.0) and +2.2 (-1.0 to +5.4) for calcium andmagnesium. In conclusion, this trial provides little evidence of an important role of combinations of cation supplements in the treatment of mild or borderline hypertension.

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Documento generato il 01/12/20 alle ore 10:35:15