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Titolo:
DELAY IN MANIFESTATIONS OF AGING BY GRAFTING NGF CULTURED CHROMAFFIN CELLS IN ADULTHOOD
Autore:
MENDOZARAMIREZ JL; BELTRANPARRAZAL L; VERDUGODIAZ L; MORGADOVALLE C; DRUCKERCOLIN R;
Indirizzi:
NATL AUTONOMOUS UNIV MEXICO,FAC MED,DEPT FISIOL MEXICO CITY 04510 DF MEXICO NATL AUTONOMOUS UNIV MEXICO,FAC MED,DEPT FISIOL MEXICO CITY 04510 DF MEXICO NATL AUTONOMOUS UNIV MEXICO,INST FISIOL CELULAR,DEPT NEUROCIENCIAS MEXICO CITY 04510 DF MEXICO
Titolo Testata:
Neurobiology of aging
fascicolo: 6, volume: 16, anno: 1995,
pagine: 907 - 916
SICI:
0197-4580(1995)16:6<907:DIMOAB>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENAL-MEDULLARY AUTOGRAFTS; NERVE GROWTH-FACTOR; DOPAMINE-DENERVATED STRIATUM; VENTRAL TEGMENTAL AREA; LONG-TERM SURVIVAL; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; AGED RATS; TYROSINE-HYDROXYLASE; BASAL GANGLIA;
Keywords:
AGING; TRANSPLANTS; NGF; MOTOR ACTIVITY; SUBSTANTIA NIGRA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
89
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Mendozaramirez et al., "DELAY IN MANIFESTATIONS OF AGING BY GRAFTING NGF CULTURED CHROMAFFIN CELLS IN ADULTHOOD", Neurobiology of aging, 16(6), 1995, pp. 907-916

Abstract

Dopamine agonists or grafts compensate impaired motor functions in aged rats. However, there is no evidence showing whether grafting in adulthood retard aging manifestations. Motor performance of 13- month-oldrats was tested on 2 meter-long wooden beams which had a 15 degrees inclination and whose thickness varied from 3, 6, 12, 18, to 24 mm. Rats at 14 months were randomly assigned to 3 groups: sham graft (Group 1); intrastriatal graft of chromaffin cells cultured with NGF (Group 2); intrastriatal graft of chromaffin cells (Group 3). Motor performancewas tested at monthly intervals up until rats were 26 months old. Twomore groups were included: 26-month-old naive rats (Group 4); and 3- to 5-month-old naive rats (Group 5) both evaluated only once. At 26 months, the basal activity of ventral mesencephalic dopaminergic neuronswas recorded. Results showed in Group 2 delay of motor detriments seen in aged rats, maintenance of basal firing rates of nigral cells comparable to those of younger rats, and greater survival of substantia nigra cells. It is suggested that NGF cultured chromaffin cells produce a delay of motor detriments in aged rats, as a result of inducing survival and firing rates of nigral cells comparable to those seen in young rats.

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Documento generato il 05/07/20 alle ore 16:15:02