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Titolo:
ULTRASTRUCTURAL-CHANGES OF THE MYOCARDIAL AND STRIATED-MUSCLE FOLLOWING A CHALLENGE OF NORMOBARIC HYPEROXIA - THE PROTECTIVE EFFECTS OF ALPHA-TOCOPHEROL
Autore:
HATZENIKOLAOU KP; GIALA MM; PARADELIS AG; CHATZINIKOLAOU PK;
Indirizzi:
ARISTOTELIAN UNIV THESSALONIKI,SCH MED,DEPT ANESTHESIA,10 ARISTOTELOUS STR GR-54623 THESSALONIKI GREECE ARISTOTELIAN UNIV THESSALONIKI,SCH MED,DEPT ANESTHESIA GR-54623 THESSALONIKI GREECE ARISTOTELIAN UNIV THESSALONIKI,SCH MED,DEPT PHARMACOL GR-54623 THESSALONIKI GREECE
Titolo Testata:
Methods and findings in experimental and clinical pharmacology
fascicolo: 8, volume: 17, anno: 1995,
pagine: 509 - 518
SICI:
0379-0355(1995)17:8<509:UOTMAS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-E; OXYGEN RADICALS; HEART;
Keywords:
NORMOBARIC HYPEROXIA; OXYGEN TOXICITY; MYOCARDIUM; DIAPHRAGM; STRIATED MUSCLES ALPHA-TOCOPHEROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
K.P. Hatzenikolaou et al., "ULTRASTRUCTURAL-CHANGES OF THE MYOCARDIAL AND STRIATED-MUSCLE FOLLOWING A CHALLENGE OF NORMOBARIC HYPEROXIA - THE PROTECTIVE EFFECTS OF ALPHA-TOCOPHEROL", Methods and findings in experimental and clinical pharmacology, 17(8), 1995, pp. 509-518

Abstract

Normobaric hyperoxia has known deleterious effects on survival, presumably due to the generation of superoxide anion and hydrogen peroxide. To investigate the anatomical substrate of the effect of normobaric hyperoxia on the myocardial and striated muscles and the protective effect, if any of alpha-tocopherol (vitamin E) on these tissues, we administered 95-99% O-2 to adult male Wistar rats for 24, 48, 60 and 72 h. The animals were divided into four groups: I) control I: six rats which breathed room air were used as controls for the ultrastructural studies; 2) control II: 10 rats which breathed 95-99% of O-2 Sor up to 72 h were used as controls for arterial pressure, blood gases/pH,PvO(2) and Hb measurements; 3) group A: hyperoxia: 24 rats divided into four subgroups according to the time of exposure to hyperoxia, A(24), A(48),A(60), A(72); and 4) group B: alpha-tocopherol/hyperoxia: 24 rats divided treated with alpha-tocopherol, 15 mg/kg/day, for 14 days before the beginning and throughout the period of hyperoxia, were divided intofour subgroups (B-24, B-48, B-60, B-72) according to the time of exposure to hyperoxia. Our results showed that: 1) up to the 60th hour, arterial pressure (MAP) was satisfactory; PaO2 > 280 mmHg; PaCO2, pH andHb were within normal limits; 2) ultrastructural studies of the myocardial apex, the diaphragm and the quadriceps femoris showed dilatationof the sarcoplasmic reticulum/T-tubuli system, swelling of mitochondria, and structural derangement of myofibrils, in particular in the z-bands. The findings were proportionally related to the time of exposureto hyperoxia. They were also more intensely shown on myocardial and diaphragmatic fibers in group A; 3) the survival time (mean +/- SD) was63.8 +/- 2.5 h in group A and 68.9 +/- 3.8 h in group B. These results suggest that normobaric hyperoxia exerts a cytotoxic effect on the myocardial and striated muscle fibers and that the administration of alpha-tocopherol may delay or change the development of oxygen toxicity.

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Documento generato il 29/03/20 alle ore 12:10:45