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Titolo:
APPLICATION OF QUANTITATIVE-ANALYSIS TO BIOLOGIC PROFILE EVALUATION IN BREAST-CANCER
Autore:
QUERZOLI P; FERRETTI S; ALBONICO G; MAGRI E; SCAPOLI D; INDELLI M; NENCI I;
Indirizzi:
UNIV FERRARA,IST ANAT ISTOL & CITOL PATOL,DEPT PATHOL,VIA FOSSATO MORTARA 64 I-44100 FERRARA ITALY ST ANNA HOSP,DIV ONCOL FERRARA ITALY
Titolo Testata:
Cancer
fascicolo: 12, volume: 76, anno: 1995,
pagine: 2510 - 2517
SICI:
0008-543X(1995)76:12<2510:AOQTBP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HER-2/NEU ONCOGENE EXPRESSION; ESTROGEN-RECEPTOR; IMMUNOCYTOCHEMICAL ANALYSIS; PROLIFERATION INDEX; PROGNOSTIC FACTORS; IMAGE-ANALYSIS; CARCINOMA; ANTIBODIES; SURVIVAL; MARKER;
Keywords:
BREAST CANCER; IMAGE ANALYSIS; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; PROLIFERATION INDEX; C-ERBB-2/NEU;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
P. Querzoli et al., "APPLICATION OF QUANTITATIVE-ANALYSIS TO BIOLOGIC PROFILE EVALUATION IN BREAST-CANCER", Cancer, 76(12), 1995, pp. 2510-2517

Abstract

Background. The biologic profile of 907 infiltrating breast carcinomas was determined considering estrogen receptor (ER) and progesterone receptor (PR), proliferation index (PI) and c-erbB-2/Neu expression. The relationship with pathologic parameters (lymph node status, size, histotype) were studied by a multivariate analysis. The clinical prognostic power of biologic profile also was evaluated for 265 patients. Methods. In 907 infiltrating breast carcinomas, the quantitation of ER, PR, an PI was obtained with an image analysis system (GAS 200, Becton Dickinson Cell Analysis Systems, San lose, CA); Neu was evaluated semiquantitatively. A clinical study of 265 patients was performed (median follow-up, 42.5 months). Results. Seventy-seven percent of tumors wereER-positive, 70% were PR-positive, 58% had a high PI, and 35% were Nea-positive. The overall analysis indicated a direct correlation between ER and PR (Spearmans' rho [rs] = 0.47, P < 0.001) and an inverse correlation between PI and ER (rs = -0.39, P < 0.001), PZ and PR (rs = -0.32, P < 0.001), Neu and ER (rs = -0.20, P < 0.001), and Neu and PR (rs = -0.21, P < 0.001). Cluster analysis, performed based on the biologic profile (ER, PR, PI, c-erbB-2/Neu expression), identified two finalgroups of tumors with different pathologic features. This study showed a longer relapse free interval for patients with ER- and PR- positive tumors (P = 0.016 and P = 0.007) and low PI and Neu-negative tumors (P < 0.001 and P = 0.047). Conclusions. These results stress the importance of the biologic profile for defining tumor behavior and patient management, leading to integration of, and eventually the substitutionfor, the actual staging system.

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Documento generato il 26/11/20 alle ore 20:22:34