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Titolo:
CRYSTAL-STRUCTURE OF THE V-ALPHA DOMAIN OF A T-CELL ANTIGEN RECEPTOR
Autore:
FIELDS BA; OBER B; MALCHIODI EL; LEBEDEVA MI; BRADEN BC; YSERN X; KIM JK; SHAO XG; WARD ES; MARIUZZA RA;
Indirizzi:
UNIV MARYLAND,MARYLAND BIOTECHNOL INST,CTR ADV RES BIOTECHNOL,9600 GUDELSKY DR ROCKVILLE MD 20850 UNIV MARYLAND,MARYLAND BIOTECHNOL INST,CTR ADV RES BIOTECHNOL ROCKVILLE MD 20850 UNIV TEXAS,SW MED CTR,CTR CANC IMMUNOBIOL DALLAS TX 75235 UNIV TEXAS,SW MED CTR,DEPT MICROBIOL DALLAS TX 75235 US FDA,CTR DRUG EVALUAT & RES ROCKVILLE MD 20857
Titolo Testata:
Science
fascicolo: 5243, volume: 270, anno: 1995,
pagine: 1821 - 1824
SICI:
0036-8075(1995)270:5243<1821:COTVDO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; 3-DIMENSIONAL STRUCTURE; MOLECULAR-STRUCTURE; VARIABLE PORTIONS; ENCEPHALOMYELITIS; RECOGNITION; ACTIVATION; CLONES; REI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Fields et al., "CRYSTAL-STRUCTURE OF THE V-ALPHA DOMAIN OF A T-CELL ANTIGEN RECEPTOR", Science, 270(5243), 1995, pp. 1821-1824

Abstract

The crystal structure of the V-alpha domain of a T cell antigen receptor (TCR) was determined at a resolution of 2.2 angstroms. This structure represents an immunoglobulin topology set different from those previously described. A switch in a polypeptide strand from one beta sheet to the other enables a pair of V-alpha homodimers to pack together to form a tetramer, such that the homodimers are parallel to each otherand all hypervariable loops face in one direction. On the basis of the observed mode of V-alpha association, a model of an (alpha beta)(2) TCR tetramer can be positioned relative to the major histocompatibility complex class II (alpha beta)(2) tetramer with the third hypervariable loop of V-alpha over the amino-terminal portion of the antigenic peptide and the corresponding loop of V-beta over its carboxyl-terminal residues. TCR dimerization that is mediated by the alpha chain may contribute to the coupling of antigen recognition to signal transduction during T cell activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:03:54