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Titolo:
REPTILIAN SEX STEROID-RECEPTORS - AMPLIFICATION, SEQUENCE AND EXPRESSION ANALYSIS
Autore:
YOUNG LJ; GODWIN J; GRAMMER M; GAHR M; CREWS D;
Indirizzi:
EMORY UNIV,SCH MED,DEPT PSYCHIAT ATLANTA GA 30322 UNIV TEXAS,INST REPROD BIOL,DEPT ZOOL AUSTIN TX 78712
Titolo Testata:
Journal of steroid biochemistry and molecular biology
fascicolo: 2, volume: 55, anno: 1995,
pagine: 261 - 269
SICI:
0960-0760(1995)55:2<261:RSS-AS>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHICKEN PROGESTERONE-RECEPTOR; MESSENGER RIBONUCLEIC-ACIDS; ESTROGEN-RECEPTOR; MOLECULAR-CLONING; COMPLEMENTARY-DNA; ANDROGEN RECEPTOR; HOMOLOGY; CDNA; IDENTIFICATION; LOCALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
L.J. Young et al., "REPTILIAN SEX STEROID-RECEPTORS - AMPLIFICATION, SEQUENCE AND EXPRESSION ANALYSIS", Journal of steroid biochemistry and molecular biology, 55(2), 1995, pp. 261-269

Abstract

Sex steroid hormones secreted by the gonads play a central role in the reproduction of all vertebrates. In addition to direct effects on gametogenesis, sex steroid hormones are important in sexual development,brain organization, and sexual behavior. The actions of sex steroid hormones are mediated primarily by ligand-dependent transcription factors, or receptors which bind to specific sequences of the DNA and alterthe transcription rates of nearby genes. We have used the polymerase chain reaction to amplify cDNA fragments of the estrogen receptor, progesterone receptor and androgen receptor from the unisexual whiptail lizard, Cnemidophorus uniparens. The lizard steroid hormone receptors share a high degree of sequence homology to the steroid hormone receptors of other vertebrates. Ribonuclease protection assays demonstrate that both estrogen receptor mRNA and progesterone receptor mRNA are increased in the oviduct during vitellogenesis and after estrogen treatment. This report demonstrates the utility of the polymerase chain reaction to generate species specific probes for comparative molecular studies and provides the first report of cDNA sequences for reptilian steroid hormone receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:50:00