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Titolo:
FINDINGS IN 100 PATIENTS WITH UNEXPLAINED HYPERCKEMIA
Autore:
KLEPPE B; REIMERS CD; ALTMANN C; PONGRATZ DE;
Indirizzi:
UNIV GOTTINGEN,KLIN NEUROPHYSIOL ABT,ROBERT KOCH STR 40 D-37075 GOTTINGEN GERMANY UNIV MUNICH,KLINIKUM INNENSTADT,MED KLIN,FRIEDRICH BAUR INST W-8000 MUNICH GERMANY
Titolo Testata:
Medizinische Klinik
fascicolo: 11, volume: 90, anno: 1995,
pagine: 623 - 627
SICI:
0723-5003(1995)90:11<623:FI1PWU>2.0.ZU;2-T
Fonte:
ISI
Lingua:
GER
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
B. Kleppe et al., "FINDINGS IN 100 PATIENTS WITH UNEXPLAINED HYPERCKEMIA", Medizinische Klinik, 90(11), 1995, pp. 623-627

Abstract

Background: In outpatient clinics for neuromuscular diseases sometimes patients are presented because oi an raised actitivity of the serum creatine kinase (CK) activity, accidentally detected. The purpose of this study was to investigate, how many patients with an unexplained hyperCKemia really suffer from a neuromuscular disease, and to present aadequate procedure for evaluating pathological CK activities. Patients and methods: In this retrospective study, clinical, electromyographic, and myopathological findings of 100 consecutive patients (38 women und 62 men, aged 19 to 78 years) with such an abnormality of unknown origin are presented. Results: Only 41 patients really had no muscular troubles and no signs of neuromuscular disorders at physical examination. The CK of 12 patients turned to normal at follow-up examination. In 4 patients a so-called makro-CK was found. In 50 patients, in-depth examinations including a muscle biopsy were performed. In 10 patients,the increased CK-activity could be attributed to a complication of analready known basic disease, e. g. by confirming a myositis in case of proven connective tissue disease. In 14 patients, an independent muscle disease was proven: 3 degenerative, 5 metabolic or mitochondrial as well as 4 inflammatory myopathies. In 2 patients, a secondary myopathy in polyneuropathy was suspected to be the etiology of the increasedCK activity. In 9 patients, well treatable disorders were discovered. In 34 patients, no muscle biopsy was performed and follow-up examinations were recommended. The ratio of the clarified diagnoses did not depend on the level of the CK activity. Conclusion: Every hyperCKemia indicates a thorough internal and neurological examination independentlyfrom the level of the enzyme activity. A scheme for examination in case of abnormal CK activity is proposed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 04:35:13