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Titolo:
RESULTS OF TREATMENT WITH THYMOPENTIN IN CHRONIC HEPATITIS-B
Autore:
TOKUS M; STAEDT U; ROSSOL S; HEENE DL; HOLM S; HOLM E;
Indirizzi:
UNIV HEIDELBERG,MED KLIN 1,PATHOPHYSIOL ABT D-68167 MANNHEIM GERMANY UNIV HEIDELBERG,MED KLIN 1,PATHOPHYSIOL ABT D-68167 MANNHEIM GERMANY
Titolo Testata:
Die medizinische Welt
fascicolo: 11, volume: 46, anno: 1995,
pagine: 530 - 535
SICI:
0025-8512(1995)46:11<530:ROTWTI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Keywords:
CHRONIC HEPATITIS B; IMMUNOMODULATION; THYMOPENTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
M. Tokus et al., "RESULTS OF TREATMENT WITH THYMOPENTIN IN CHRONIC HEPATITIS-B", Die medizinische Welt, 46(11), 1995, pp. 530-535

Abstract

In a study using thymopentin as a possible therapeutic agent in chronic active hepatitis B, 8 outpatients were treated. During a first treatment period of 11 to 22 weeks with 100 mg of thymopentin being administered s. c. 1-3 times per week, the ASAT activity decreased from 176 /- 99 to 15 +/- 3 (SD) U/I (p < 0.01); HBe-AG and HBV-DNA showed seroconversion. Following either discontinuation or dose reduction oi thymopentin therapy, a reactivation of the disease necessitated a second treatment period in 4 patients and a third one in 2 patients; these patients thus became their own control. Within 7 to 19 weeks, the transaminases returned again to either normal or almost normal values, and the viral replication markers seroconverted about the same timer The follow-up time span over which 7 patients continued to receive thymopentin was 130 +/- 82 (SD) weeks with normal ASAT activities in 6 cases andmoderately raised activities in 2 cases. Histological re-examination of the liver revealed a clear-cut reversal of inflammation and cell necrosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/08/20 alle ore 14:33:36