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Titolo:
RESULTS OF THE ENDOPHTHALMITIS VITRECTOMY STUDY - A RANDOMIZED TRIAL OF IMMEDIATE VITRECTOMY AND OF INTRAVENOUS ANTIBIOTICS FOR THE TREATMENT OF POSTOPERATIVE BACTERIAL ENDOPHTHALMITIS
Autore:
VINE AK; BLODI BA; ELNER SG; JOHNSON MW; JESSUP LM; PIERSON CL; WILLIS J; MCIVER F; STANLEY S; SNEED SR; CAPONE A; AABERG TM; LIM JI; STERNBERG P; COFFMAN DS; MOORE CN; GARDNER SK; NOLTE FS; FREMSTAD A; GIBBS D; GILMAN J; SWORDS R; AGUILAR HE; MEREDITH TA; LAKHANPAL V; CHRISTIAN FD; HOOD MA; SCHWALBE RS; BILLINGS EE; BUIE W; MALLONEE JJ; MILLAR MA; VERBEEK S; CAMPOCHIARO PA; PALARDY CB; REYNOLDS L; DICK JD; CAIN D; DAMICO DJ; FREDERICK AR; MORLEY MG; PESAVENTO RD; PULIAFITO CA; TOPPING TM; FINN SM; RAYMOND LA; BAKER AS; PATON B; EVANS C; NAPOLI J; KIEMAN C; MAKRIS K; REIDY WT; WHITE R; GARFINKEL RA; PILKERTON AR; FRANTZ RA; ABERNATHY GB; BARBACCIA JG; ENSEY HR; ORMES CA; PARK CH; CAPLAN J; RUSSELL K; TOMA R; PACKO KH; DEBUSTROS S; FLOOD TP; GLAZER L; DEALBA M; EVANICH E; MONTWILL MA; ROTHMAN JJ; RUDERMAN G; BEARD M; LANDAU W; SHEN MH; GORDON M; GRAFF S; KWIATKOWSKI K; PAPPAS L; BRYANT D; DOHERTY D; MORINI F; ARREDONDO L; GARRETSON BR; GERENA C; HUNT M; KINNAIRD SM; RICE TA; NOVAK MA; ROWE PS; JAMIESON S; NEWBERY D; RECH GR; DUL MJ; KINSER L; STROZEWSKI K; CLARKRATH S; DELISIO M; DEMPSEY DL; KUKULA D; PINTERSMITH A; SMITHBREWER S; LUDWIG T; CHAMBERS RB; DAVIDORF FH; TAYLOR CS; HALE KN; BUESCHING WJ; CHAUDHURI C; SHORTLIDGE GR; COVER NJ; KEATING MJ; SAVAGE SJ; ANDRZEJEWSKA P; CORNETET S; MILLIRON JD; RICHMOND R; SCHNEIDER L; WEISENBERGER D; CANTRILL HL; RAMSAY RC; BRALLIER AB; JOHNSON TP; ROSSING EE; KNAUTH KA; MONAHAN MM; OESTREICH NW; CLARK KF; GLENNEN AM; YARIAN DL; GREEN SN; LEFF SR; MASCIULLI L; LUCIDO MM; LUDWIG EJ; MARANO CL; PETERS L; JOHO K; VOLKERT DC; ANDERSEN F; COFFEY D; SCHLOSSER A; HONEYWELL A; MAMES RN; DRIEBE WT; STERN GA; FRANCIS A; ZAM ZS; COOPER R; GASKINS D; SHAMIS DJ; WILLINGHAM M; BARKER K; ROSA H; FRIEDMAN SM; GARDNER TW; BLANKENSHIP GW; COYLE CJ; BERO CJ; HALAS C; SCHICK S; WALKER J; CUNNINGHAM D; LAMBERT HM; CLOGSTON PS; GARDNER SN; OSATO MS; FRADY PM; CARR L; SHIGLEY J; LOPEZ PF; CHONG LP; CISNEROS L; PADILLA M; YEE EM; NAKAMURA T; WALONKER AF; NICHOLS T; HUETE ME; LIGGETT PE; OBER RR; QUILLENTHOMAS B; WILLIAMS M; BARR CC; BLOOM SM; GREENE PJ; WHITTINGTON GK; MARTIN ME; WATSON G; JENKINSCURRY B; GILKEY LA; HUELSMAN S; HAN DP; BURTON TC; MIELER WF; PULIDO JS; REESER FH; NEWMAN JL; WERNER KA; PISARZEWICZ PJ; REINERIO NA; WALLOCH MLK; WILMER Z; LAABS J; PHILLIPS J; PICCHIOTTINO R; WIPPLINGER W; ABRAMS GW; JURKIEWICZ DT; LEET ML; MANDEL P; METZGER K; SUCHLA L; ZARLING D; BALLES MW; RYAN EH; KNOBLOCH WH; COOK SM; LUKE DG; FERRIERI P; SCHIMINSKY NM; GENIA A; PHILIPH DA; STINSON EK; WRIGHT LM; MCMICHAEL MC; MIELKE SJ; PONWITH LJ; PAVAN PR; PAUTLER SE; COATS ML; KIRK NM; MILLARD SM; CASTELLANO FC; EDWARDS CR; MARQUARDT A; MCCORMACK AJ; MCCORMICK MT; RENSHAW B; RESTUCCIA A; CAMPBELL M; CHRISTOPHER N; GARRETT LS; HALKIAS DG; HOTHERSALL K; MICKLER K; MINNICK TS; BURR C; SAXON W; ARCACHA MA; CARLTON S; EDISON SK; MALLIS MJ; SAYERS TL; SUDDS TW; TIBERIA RJ; WOLABAUGH S; BRADFORD RH; PARKE DW; WOLF TC; SHOFNER LM; TOBEY LE; JENSEN HG; SANCHEZ D; SHOFNER J; BURRIS R; DRAKE KK; GRISSOM KR; ROWSEY JJ; WILKINSON CP; BROWN GC; BENSON WE; FEDERMAN JL; LUCIER AC; MAGUIRE JI; SARIN LK; SHAKIN EP; SIVALINGAM A; TASMAN W; VANDER JF; WARD N; WEISBECKER CA; AGNEW CL; LAMBERT R; TOMER T; CARLSON K; RANCHINE G; SERFASS MS; DOFT BH; BERGREN RL; LOBES LA; OLSEN KR; RINKOFF JS; METZ DJ; LEONARD MN; KARENCHAK LM; KOWALSKI RP; WELLMAN LA; WILCOX LA; CAMPBELL AF; STEINBERG DR; VAGSTAD GL; FLOOK KA; GOOD MM; KEENEN BJ; MELLINGER KA; MARGHERIO RR; COX MS; MURPHY PL; LUCAROTTI R; MARTIN S; BAND J; BOSTIC G; CUMMING K; MANATREY PE; MITCHELL B; REGAN VS; BRIDGES C; COX S; HOUSTON G; JOHNSON J; STREASIK P; WOOD B; BLUMENKRANZ MS; CAYO L; KAYE V; VALENZUELA CL; ORGEL IK; POLINER LS; TORNAMBE PE; CANNON SV; NIELSEN JL; CARLSON A; CHAN P; DRAKE L; GRIM M; PETERSON C; BORG LA; GILLYATT J; BEYER C; HAMMER ME; GRIZZARD WS; SHANNON TL; TRAYNOM JR; COLLADO MJ; MCMANUS DW; SWEENEY DE; ADAMS DH; WATSON TT; ANTWORTH MV; ARAOS JG; GREENWALD MA; HABIB M; MYERS SK; OCKERS KM; THIBODEAU JA; WATKINS B; FRAMBACH DA; MORALES R; NELSEN PT; ROSENTHAL JG; MINTZ FV; BIEDENBACH M; LEONARDY NJ; ORGER IK; LAWNICZAK SM; BORK C; HAGEAGE G; HUNTER EB; MARSHALL MJ; ROMAN P; HILL R; HOFBAUER T; LEMANOWICZ J; CUPPLES HP; GUZMAN GI; BRODEUR RJ; YEE D; DELAHA EC; GEYER SL; SLOVIS S; SHIELDS W; LAUBER S; MICHELITSCH K;
Indirizzi:
EVS COORDINATING CTR,127 PARRAN HALL,130 DESOTO ST PITTSBURGH PA 15261 EMORY EYE CTR ATLANTA GA 00000 UNIV MARYLAND,EYE ASSOCIATES BALTIMORE MD 21201 JOHNS HOPKINS UNIV BALTIMORE MD 21218 MASSACHUSETTS EYE & EAR INFIRM BOSTON MA 02114 RETINA GRP WASHINGTON CHEVY CHASE MD 00000 RUSH UNIV,INGALLS HOSP CHICAGO IL 60612 RETINA ASSOCIATES INC CLEVELAND OH 00000 OHIO STATE UNIV COLUMBUS OH 43210 UNIV MINNESOTA EDINA MN 00000 RETINA VITREOUS CTR PA EDISON PA 00000 UNIV FLORIDA GAINESVILLE FL 32611 PENN STATE UNIV HERSHEY PA 17033 BAYLOR COLL MED HOUSTON TX 77030 UNIV SO CALIF LOS ANGELES CA 90089 UNIV LOUISVILLE,KENTUCKY LIONS EYE RES INST LOUISVILLE KY 40292 MED COLL WISCONSIN MILWAUKEE WI 53226 UNIV MINNESOTA MINNEAPOLIS MN 55455 UNIV S FLORIDA N TAMPA FL 00000 DEAN A MCGEE EYE INST OKLAHOMA CITY OK 00000 THOMAS JEFFERSON UNIV,WILLS EYE HOSP PHILADELPHIA PA 19107 ASSOCIATED RETINAL CONSULTANTS PC ROYAL OAK MI 00000 RETINA CONSULTANTS SAN DIEGO CA 00000 UNIV S FLORIDA S TAMPA FL 00000 RETINA CONSULTANTS NW OHIO TOLEDO OH 00000 RETINA VITREOUS ASSOCIATES INC TOLEDO OH 00000 GEORGETOWN UNIV WASHINGTON DC 20057 RETINA VITREOUS CONSULTANTS PITTSBURGH PA 00000 TUFTS UNIV NEW ENGLAND MED CTR BOSTON MA 02111 EYE ASSOCIATES ALBANY NY 00000 EYE & EAR INST PITTSBURGH PITTSBURGH PA 15213 UNIV MISSOURI COLUMBIA MO 65211 UNIV PITTSBURGH,MED CTR PITTSBURGH PA 15260 UNIV PITTSBURGH,CTR COORDINATING PITTSBURGH PA 15260 UNIV WISCONSIN,CTR PHOTOGRAPH READING MADISON WI 53706 CARNEGIE MELLON UNIV PITTSBURGH PA 15213 DUKE UNIV,CTR EYE DURHAM NC 27706 NIH BETHESDA MD 20892 UNIV ILLINOIS CHICAGO IL 60680 NEI,PROGRAM OFF BETHESDA MD 20892 UNIV WASHINGTON SEATTLE WA 98195 UNIV MICHIGAN ANN ARBOR MI 48109
Titolo Testata:
Archives of ophthalmology
fascicolo: 12, volume: 113, anno: 1995,
pagine: 1479 - 1496
SICI:
0003-9950(1995)113:12<1479:ROTEVS>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFECTIOUS ENDOPHTHALMITIS; INTRAVITREAL GENTAMICIN; MANAGEMENT; CEPHALOSPORIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Vine et al., "RESULTS OF THE ENDOPHTHALMITIS VITRECTOMY STUDY - A RANDOMIZED TRIAL OF IMMEDIATE VITRECTOMY AND OF INTRAVENOUS ANTIBIOTICS FOR THE TREATMENT OF POSTOPERATIVE BACTERIAL ENDOPHTHALMITIS", Archives of ophthalmology, 113(12), 1995, pp. 1479-1496

Abstract

Objective: To determine the roles of immediate pars plana vitrectomy (VIT) and systemic antibiotic treatment in the management of postoperative endophthalmitis. Design: Investigator-initiated, multicenter, randomized clinical trial. Setting: Private and university-based retina-vitreous practices. Patients: A total of 420 patients who had clinical evidence of endophthalmitis within 6 weeks after cataract surgery or secondary intraocular lens implantation. Interventions: Random assignment according to a 2 X 2 factorial design to treatment with VIT or vitreous tap or biopsy (TAP) and to treatment with or without systemic antibiotics (ceftazidime and amikacin). Main Outcome Measures: A 9-month evaluation of visual acuity assessed by an Early Treatment Diabetic Retinopathy Study acuity chart and media clarity assessed both clinically and photographically. Results: There was no difference in final visual acuity or media clarity with or without the use of systemic antibiotics. In patients whose initial visual acuity was hand motions or better, there was no difference in visual outcome whether or not an immediate VIT was performed. However, in the subgroup of patients with initial light perception-only vision, VIT produced a threefold increase in the frequency of achieving 20/40 or better acuity (33% vs 11%), approximately a twofold chance of achieving 20/100 or better acuity (56% vs 30%), and a 50% decrease in the frequency of severe visual loss (20% vs 47%) over TAP. In this group of patients, the difference between VITand TAP was statistically significant (P < .001, log rank test for cumulative visual acuity scores) over the entire range of vision. Conclusions: Omission of systemic antibiotic treatment can reduce toxic effects, costs, and length of hospital stay. Routine immediate VIT is nor necessary in patients with better than light perception vision at presentation but is of substantial benefit for those who have light perception-only vision.

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Documento generato il 02/04/20 alle ore 09:18:45