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Titolo:
DIETARY VITAMIN-E MODULATION OF CYTOKINE PRODUCTION BY SPLENOCYTES AND THYMOCYTES FROM ALCOHOL-FED MICE
Autore:
WANG YJ; HUANG DS; WATSON RR;
Indirizzi:
UNIV ARIZONA,DEPT FAMILY & COMMUNITY MED TUCSON AZ 85724 UNIV ARIZONA,DEPT FAMILY & COMMUNITY MED TUCSON AZ 85724 UNIV ARIZONA,NUTR SCI PROGRAM TUCSON AZ 85721 UNIV ARIZONA,ALCOHOL RES CTR TUCSON AZ 00000 UNIV ARIZONA,DEPT MICROBIOL & IMMUNOL TUCSON AZ 85721
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 2, volume: 18, anno: 1994,
pagine: 355 - 362
SICI:
0145-6008(1994)18:2<355:DVMOCP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
KILLER-CELL-ACTIVITY; ETHANOL-CONSUMPTION; SUPEROXIDE PRODUCTION; LIPID-PEROXIDATION; LIVER-DISEASE; IMMUNE; THYMUS; IMMUNOMODULATION; CORTICOSTERONE; INTERLEUKIN-5;
Keywords:
VITAMIN E; ETHANOL; CYTOKINES; T-CELL MATURATION; IMMUNOGLOBULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
Y.J. Wang et al., "DIETARY VITAMIN-E MODULATION OF CYTOKINE PRODUCTION BY SPLENOCYTES AND THYMOCYTES FROM ALCOHOL-FED MICE", Alcoholism, clinical and experimental research, 18(2), 1994, pp. 355-362

Abstract

As vitamin E enhances immune responses, it may reduce dietary ethanol(EtOH) induced immune suppression, thereby favorably affecting host disease resistance. The effects of dietary vitamin E at higher level inalcohol-fed female C57BL/6 mice was determined via in vitro cytokine production by splenocytes and thymocytes, and some other immune functions. A 15-fold increase of vitamin E (160 IU/liter) in a liquid diet (National Council Research), with or without EtOH (4.5%, v/v), was fed to mice for 10 weeks. Vitamin E supplementation restored production ofinterleukin-2, -5, -6, -10, and interferon-gamma by concanavalin A (Con A)-stimulated splenocytes and interleukin-6 and tumor necrosis factor-alpha by lipopolysaccharide-stimulated splenocytes, which were suppressed by dietary EtOH. However, it had no effect on interleukin-4 secretion, which was also reduced by splenocytes from EtOH-fed mice. Vitamin E supplementation also restored EtOH-suppressed, mitogen induced splenocyte proliferation, but not thymocyte proliferation, although it slightly increased production of immunoglobulin A and G by lipopolysaccharide-stimulated splenocytes, which were suppressed by dietary EtOH. Dietary vitamin E, furthermore, significantly increased interleukin-2and -6 secretion by Con A-stimulated thymocytes, which were suppressed by dietary EtOH, although it had no effect on interleukin-4 and interferon-gamma production by Con A-stimulated thymocytes from EtOH-fed mice. These data suggest that dietary vitamin E supplementation can modulate dysregulation of cytokines initiated by dietary EtOH and restoreimmune dysfunctions induced by EtOH ingestion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:40:13