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Titolo:
INFLUENCE OF HELICOBACTER-PYLORI ON TRYPTASE AND CATHEPSIN-D IN PEPTIC-ULCER
Autore:
PLEBANI M; BASSO D; RUGGE M; VIANELLO F; DIMARIO F;
Indirizzi:
CENT LAB,DIPARTIMENTO MED LAB,VIA GIUSTINIANI 2 I-35128 PADUA ITALY UNIV PADUA,IST MED LAB PADUA ITALY UNIV PADUA,CATTEDRA GASTROENTEROL PADUA ITALY UNIV PADUA,USL 19,CATTEDRA ISTOCHIM & IMMUNOISTOCHIM PATOL PADUA ITALY
Titolo Testata:
Digestive diseases and sciences
fascicolo: 11, volume: 40, anno: 1995,
pagine: 2473 - 2476
SICI:
0163-2116(1995)40:11<2473:IOHOTA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAST-CELLS; DISEASE; TISSUE;
Keywords:
PEPTIC ULCER; TRYPTASE; CATHEPSIN D; HELICOBACTER PYLORI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
M. Plebani et al., "INFLUENCE OF HELICOBACTER-PYLORI ON TRYPTASE AND CATHEPSIN-D IN PEPTIC-ULCER", Digestive diseases and sciences, 40(11), 1995, pp. 2473-2476

Abstract

We here ascertain whether tryptase (a serine endoprotease released bymast cells) and cathepsin D (CD, a lysosomal hydrolase that seems able to derange the extracellular matrix) play a part in peptic ulcer disease and whether they are linked to Helicobacter pylori (Hp) infection. We studied 13 controls, 25 patients with gastric ulcer, 47 with duodenal ulcer, and 11 with duodenitis. Tryptase and CD were measured in mucosal biopsies (body and antrum of the stomach and duodenum) using IRMA methods, Hp infection was histologically evaluated (Giemsa). Tryptase and CD levels were higher (25%) in patients with active peptic ulcer, whether gastric or duodenal, In Hp-positive patients the CD mucosalcontent was higher while tryptase mucosal levels were lower than in Hp-negative patients. Tryptase was correlated with gastrin content, CD seems to be mainly related to the phlogistic reaction of the mucosa toHp infection; tryptase may reflect an indirect link between Hp infection, gastrin release, and the function of mast cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 11:07:38