Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IS NORMOBARIC SIMULATION OF HYPOBARIC HYPOXIA ACCURATE IN CHRONIC AIR-FLOW LIMITATION
Autore:
NAUGHTON MT; ROCHFORD PD; PRETTO JJ; PIERCE RJ; CAIN NF; IRVING LB;
Indirizzi:
ALFRED HOSP,DEPT RESP MED,COMMERCIAL RD PRAHRAN VIC 3181 AUSTRALIA HEIDELBERG HOSP,DEPT THORAC MED HEIDELBERG VIC AUSTRALIA AUSTIN HOSP,DEPT THORAC MED HEIDELBERG VIC AUSTRALIA
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 6, volume: 152, anno: 1995,
pagine: 1956 - 1960
SICI:
1073-449X(1995)152:6<1956:INSOHH>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; AIR-TRAVEL; HYPOXEMIA; PASSENGERS; ALTITUDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Naughton et al., "IS NORMOBARIC SIMULATION OF HYPOBARIC HYPOXIA ACCURATE IN CHRONIC AIR-FLOW LIMITATION", American journal of respiratory and critical care medicine, 152(6), 1995, pp. 1956-1960

Abstract

Hypobaric hypoxemia is experienced by passengers during commercial aircraft flight. In order to assess the extent of hypoxemia and to test whether hypobaric hypoxia can be accurately estimated at sea level, the results of the normobaric hypoxia altitude simulation test (N-HAST) were compared with those of the hypobaric hypoxia altitude simulation test (H-HAST) in six normal control subjects and nine patients with chronic airflow limitation (CAL) at simulated cabin altitudes of 6,000 ft (1,829 m) and both at rest and during exercise at 8,000 ft (2,438 m). Serial arterial blood samples were drawn during the breathing of 15.1 and 16.3% inspired oxygen at sea level (N-HAST) at rest and during light exercise, and during the breathing of room air at simulated cabinaltitudes (H-HAST) of 609 mm Hg (6,000 ft) and 565 mm Hg (8,000 ft) at rest and during light exercise. As measured with the H-HAST technique, the mean (+/-SD) Pa-O2 of the normal group fell from 96.2 +/- 6.2 mm Hg (sea level) to 70.1 +/- 6.0 mm Hg (6,000 ft), and to 61.7 +/- 1.6mm Hg (8,000 ft at rest) and 54.8 +/- 7.1 mm Hg (8,000 ft during exercise) (p < 0.005 by analysis of variance [ANOVA]). In the CAL group, the mean (+/- SD) Pa-O2 fell from 75.8 +/- 8.2 mm Hg (sea level) to 57.0 +/- 6.3 mm Hg (6,000 ft), and 49.5 +/- 6.1 mm Hg (8,000 ft at rest),and 38.6 +/- 7.5 mm Hg (8,000 ft during exercise) (p < 0.005 by ANOVA). There were no significant differences in Pa-O2 Pa-CO2, or pH as assessed by the N-HAST and H-HAST techniques in either the normal or the CAL patient groups. These findings suggest that in both the CAL and normal groups: (1) the N-HAST is an accurate predictor of hypobaric hypoxemia at altitudes of 6,000 and 8,000 ft; (2) light exercise at altitude causes precipitous reductions in Pa-O2; and (3) a steady-state Pa-O2 at altitude is reached within 5 min.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 17:29:33