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Titolo:
PERIPHERAL AIRWAYS RESPONSIVENESS TO COOL, DRY AIR IN NORMAL AND ASTHMATIC INDIVIDUALS
Autore:
KAMINSKY DA; IRVIN CG; GURKA DA; FELDSIEN DC; WAGNER EM; LIU MC; WENZEL SE;
Indirizzi:
UNIV VERMONT,COLL MED,GIVEN C-317 BURLINGTON VT 05405 UNIV COLORADO,HLTH SCI CTR,NATL JEWISH CTR IMMUNOL & RESP MED,DEPT MED,DIV PULM SCI & CRIT CARE DENVER CO 00000 JOHNS HOPKINS UNIV,CTR ASTHMA & ALLERGY,DEPT MED,DIV PULM & CRIT CAREMED BALTIMORE MD 21224
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 6, volume: 152, anno: 1995,
pagine: 1784 - 1790
SICI:
1073-449X(1995)152:6<1784:PARTCD>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXERCISE-INDUCED ASTHMA; COLLATERAL VENTILATION; SITE; MODELS; TREE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Kaminsky et al., "PERIPHERAL AIRWAYS RESPONSIVENESS TO COOL, DRY AIR IN NORMAL AND ASTHMATIC INDIVIDUALS", American journal of respiratory and critical care medicine, 152(6), 1995, pp. 1784-1790

Abstract

Peripheral airways resistance (Rp) has been shown to be increased in asymptomatic asthmatic patients with normal spirometric values, and tobe correlated with airways hyperresponsiveness to methacholine. We investigated whether Rp in asthmatic subjects with exercise-induced bronchospasm (EIB) would rise in response to cool, dry air. Using a wedgedbronchoscope technique, we challenged an isolated lung segment with high flows (500 to 1,000 ml/min) of cool (22 degrees C) dry 5% CO2 in air for 5 min in eight asthmatic subjects with EIB and eight normal subjects. Baseline Rp and Rp following challenge were measured with saturated air at 37 degrees C at a flow rate of 100 ml/min. Baseline Rp wassignificantly greater in the asthmatic (0.09; [0.05 to 0.23] cm H2O/ml/min; median [interquartile range]) than in the normal subjects (0.05; [0.03 to 0.07] cm H2O/ml/min) (p = 0.04). The asthmatic, but not thenormal subjects, had a significant absolute maximal increase in Rp following cool, dry air (0.10 [0.03 to 0.15] cm H2O/ml/min) (p < 0.01). In the asthmatic subjects, baseline Rp correlated with airways hyperresponsiveness to exercise (r = -0.76, p = 0.03). We conclude that the peripheral airways of asthmatic individuals with EIB are responsive to cool, dry air, and may play an important role in EIB.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 13:42:48