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Titolo:
THROMBOTIC THROMBOCYTOPENIC PURPURA - INDICATIONS FOR AND RESULTS OF SPLENECTOMY
Autore:
WINSLOW GA; NELSON EW;
Indirizzi:
UNIV UTAH,HLTH SCI CTR,DEPT SURG SALT LAKE CITY UT 84132 UNIV UTAH,HLTH SCI CTR,DEPT SURG SALT LAKE CITY UT 84132
Titolo Testata:
The American journal of surgery
fascicolo: 6, volume: 170, anno: 1995,
pagine: 558 - 563
SICI:
0002-9610(1995)170:6<558:TTP-IF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-EXCHANGE; EXPERIENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Winslow e E.W. Nelson, "THROMBOTIC THROMBOCYTOPENIC PURPURA - INDICATIONS FOR AND RESULTS OF SPLENECTOMY", The American journal of surgery, 170(6), 1995, pp. 558-563

Abstract

BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening disorder of unknown pathophysiology. The role of splenectomy in the multimodality therapy of TTP is controversial. MATERIALS AND METHODS: All charts of patients with TTP at the University of Utah between 1984 and 1994 were reviewed to evaluate various treatment regimens, and specifically, the impact of splenectomy on morbidity and survival. RESULTS: Of the 15 patients identified, 14 underwent initial treatment with plasmapheresis and steroids. Nine patients were treated with medical therapy only, 6 of whom completely recovered, while 3 patients. Six patients failed plasmapheresis and underwent splenectomy. There were no operative complications or postoperative deaths. All surgical patients had no active disease at last follow-up. CONCLUSION: Plasmapheresis and steroid administration remain the first-line therapy forTTP. This series documents that splenectomy offers excellent results with minimal morbidity and mortality in patients who do not respond toor who relapse after plasmapheresis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 14:58:54