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Titolo:
EXPRESSION OF COSTIMULATORY MOLECULES B7-1 (CD80), B7-2 (CD86), AND INTERLEUKIN-12 CYTOKINE IN MULTIPLE-SCLEROSIS LESIONS
Autore:
WINDHAGEN A; NEWCOMBE J; DANGOND F; STRAND C; WOODROOFE MN; CUZNER ML; HAFLER DA;
Indirizzi:
BRIGHAM & WOMENS HOSP,CTR NEUROL DIS,MOLEC IMMUNOL LAB,LMRC 113,221 LONGWOOD AVE BOSTON MA 02115 BRIGHAM & WOMENS HOSP,CTR NEUROL DIS,MOLEC IMMUNOL LAB BOSTON MA 02115 HARVARD UNIV,SCH MED BOSTON MA 02115 INST NEUROL,MULTIPLE SCLEROSIS LAB LONDON WC1N 1PJ ENGLAND
Titolo Testata:
The Journal of experimental medicine
fascicolo: 6, volume: 182, anno: 1995,
pagine: 1985 - 1996
SICI:
0022-1007(1995)182:6<1985:EOCMB(>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; TUMOR-NECROSIS-FACTOR; CELL STIMULATORY FACTOR; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CTLA-4 COUNTER-RECEPTOR; FACTOR-ALPHA; T-CELLS; ALLERGIC ENCEPHALOMYELITIS; LYMPHOCYTES-T; CLONAL ANERGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
A. Windhagen et al., "EXPRESSION OF COSTIMULATORY MOLECULES B7-1 (CD80), B7-2 (CD86), AND INTERLEUKIN-12 CYTOKINE IN MULTIPLE-SCLEROSIS LESIONS", The Journal of experimental medicine, 182(6), 1995, pp. 1985-1996

Abstract

Resting autoreactive T cells are present in the circulation of normalindividuals without pathologic consequences. In autoimmune animal models, stimulation of these self-reactive T cells in the presence of costimulatory molecules B7-1 results in T cell-mediated autoimmune disease, whereas B7-2 stimulation generates regulatory autoreactive T cells that abrogate disease severity. Thus, reactivation in the brain of myelin-autoreactive T cells by antigen with costimulatory molecules may be a critical event in the pathophysiology of multiple sclerosis (MS), a putative autoimmune disease of central nervous system (CNS) myelin. We investigated the expression of cytokines and costimulatory molecules in a panel of 41 histologically characterized CNS specimens from 15 MS and 10 control cases using semiquantitative reverse transcriptase-polymerase chain reaction and immunocytochemistry. In four cases, vascular CNS infarcts with inflammation were compared with MS plaques from the same brain. We observed increased expression of B7-1 and interleukin (IL) 12p40 in acute MS plaques, particularly from early disease cases but not in inflammatory infarcts. B7-1 staining was localized predominantly to the lymphocytes in perivenular inflammatory cuffs but not the parenchyma. In contrast, B7-2 was expressed predominantly on macrophages both in MS lesions of varied time duration and in inflammatory infarcts. These findings indicate that an early event in the initiation of MS involves upregulation of B7-1 and IL-12, resulting in conditions that maximally stimulate T cell activation and induction of T helper 1-type immune responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:14:46