Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
UP-REGULATION OF A NON-ET(A) RECEPTOR IN HUMAN ARTERIES IN-VITRO
Autore:
ADNER M; ERLINGE D; NILSSON L; EDVINSSON L;
Indirizzi:
UNIV LUND HOSP,DEPT CELL BIOL 1,EB BLOCKET S-22185 LUND SWEDEN UNIV LUND HOSP,DEPT INTERNAL MED,DIV EXPTL VASC RES S-22185 LUND SWEDEN
Titolo Testata:
Journal of cardiovascular pharmacology
, volume: 26, anno: 1995, supplemento:, 3
pagine: 314 - 316
SICI:
0160-2446(1995)26:<314:UOANRI>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIN;
Keywords:
ET-1; ET-3; IRL 1620; RECEPTOR UP-REGULATION; NON-ET(A) RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
M. Adner et al., "UP-REGULATION OF A NON-ET(A) RECEPTOR IN HUMAN ARTERIES IN-VITRO", Journal of cardiovascular pharmacology, 26, 1995, pp. 314-316

Abstract

Receptor turnover may be a crucial part in the physiology of endothelin (ET). Incubation of vessel segments could be a possible method to demonstrate this. The aim was to study contractile responses of human omental arteries to different ET agonists at various periods after incubation at 37 degrees C in 5% CO2 and air. The maximum effect (E(max); percentage of contraction to 60 mM K+ buffer solution) and the potencyof ET-1 were unaltered (pD(2) = 8.82 +/- 0.06). The selective ET(B) agonist IRL 1620 demonstrated a negligible E(max) in nonincubated seg segments (2.4 +/- 0.9%). After only 1 day of incubation the E(max) was 51 +/- 23%, and it reached 114 +/- 53% after 5 days. The pD(2) of IRL 1620 was stable throughout the incubation time (7.23 +/- 0.08). ET-3 showed a moderate E(max) in nonincubated segments (55 +/- 18%), with a pD(2) of 6.68 +/- 0.24. However, subsequent incubation revealed an increase of pD(2) to 8.60 +/- 0.20 on the fifth day. The maximum contraction increased to 206 +/- 44%; this is equal to the contraction obtained in paired experiments with ET-1 (215 +/- 18%). These findings indicate modulation of endothelin receptor expression after incubation of vessel segments, and suggest the gradual appearance of a non-ET(A) receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:27:15