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Titolo:
R-TYPE CALCIUM-CHANNEL INVOLVED IN ENDOTHELIN-1-INDUCED CONTRACTION OF RABBIT AORTA
Autore:
BENCHEKROUN MT; GROSLOUIS N; BKAILY G; DORLEANSJUSTE P;
Indirizzi:
UNIV SHERBROOKE,FAC MED,DEPT PHYSIOL & BIOPHYS SHERBROOKE PQ J1H 5N4 CANADA UNIV SHERBROOKE,FAC MED,DEPT PHARMACOL SHERBROOKE PQ J1H 5N4 CANADA
Titolo Testata:
Journal of cardiovascular pharmacology
, volume: 26, anno: 1995, supplemento:, 3
pagine: 300 - 302
SICI:
0160-2446(1995)26:<300:RCIIEC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; RECEPTOR; POTENT; IRL-1620; AGONIST;
Keywords:
ENDOTHELIUM; ENDOTHELIN-1; R-TYPE CA2+ CHANNEL; CA2+ ANTAGONISTS; BQ-788;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
M.T. Benchekroun et al., "R-TYPE CALCIUM-CHANNEL INVOLVED IN ENDOTHELIN-1-INDUCED CONTRACTION OF RABBIT AORTA", Journal of cardiovascular pharmacology, 26, 1995, pp. 300-302

Abstract

The mechanism of Ca2+ mobilization induced by endothelin-1 (ET-1) andthe receptor subtype responsible for this effect were examined in therabbit aorta. We have used preparations with intact and denuded endothelium. Experiments were designed to measure both Fura-2-[Ca](i) fluorescence and contractile tension simultaneously. In both preparations, ET-1 (10(-10) to 10(-7) M) induced contractions and increases of the fluorescence ratio in a concentration-dependent manner. ET-1-induced contractions and elevations of [Ca](i) were blocked by the dual L- and R-type calcium-channel blocker (-)PN200 110 (10(-6) M), whereas nifedipine (10(-6) M) affected only the latter parameter. BQ-123, a selectiveET(A) receptor antagonist, almost totally blocked the ET-1-induced contraction and elevation of [Ca](i). Our results illustrate the activation of the R-type calcium channel by ET-1 on the smooth muscle and on the endothelium rabbit aorta. This effect of ET-1 on the R-type calcium channel is mediated by ET(A) and ET(B) receptor stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:37:35