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Titolo:
IN-VIVO HEMODYNAMIC AND INOTROPIC EFFECTS OF THE ENDOTHELIN, AGONIST IRL-1620
Autore:
BEYER ME; SLESAK G; HOFFMEISTER HM;
Indirizzi:
UNIV TUBINGEN,MED KLIN,ABT 3,OTFRIED MULLER STR 10 D-72076 TUBINGEN GERMANY
Titolo Testata:
Journal of cardiovascular pharmacology
, volume: 26, anno: 1995, supplemento:, 3
pagine: 190 - 192
SICI:
0160-2446(1995)26:<190:IHAIEO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE AGONIST; RAT AORTA; IRL-1620; HEART; CONTRACTILITY; RECEPTOR; POTENT; ATRIA;
Keywords:
IRL 1620; ENDOTHELIN(B) RECEPTOR AGONIST; ENDOTHELIN RECEPTORS; CONTRACTILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Beyer et al., "IN-VIVO HEMODYNAMIC AND INOTROPIC EFFECTS OF THE ENDOTHELIN, AGONIST IRL-1620", Journal of cardiovascular pharmacology, 26, 1995, pp. 190-192

Abstract

The endothelin(B) (ET(B)) receptor is involved in endothelin-induced vasoconstriction and appears to play a role in ET-induced positive inotropy. Our previous study could not detect a positive inotropic effectof ET-1 in vivo. To evaluate specifically the effects of the ET(B) receptor on hemodynamics and inotropy of ET-1 in the intact circulation,we examined in the open-chest rat model the dose-dependent hemodynamic and inotropic effects of the highly specific ET(B) agonist IRL 1620 (0.4, 1.0, 2.0, and 4.0 nmol/kg vs. NaCl controls) during and after a 7-min infusion. In addition to measurements in the intact circulation,isovolumic recordings (peak LVSP, peak dP/dt(max)) were performed forquantification of myocardial contractility independently of peripheral vascular changes. IRL 1620 caused a significant biphasic blood pressure response with an initial fall and a sustained increase, reflectingthe vasoactive effects of IRL 1620, with a transient vasorelaxation followed by dose-dependent and long-lasting vasoconstriction. Although IRL 1620 has a positive chronotropic effect the reduction in stroke volume (probably due to the elevated afterload) causes a decrease in cardiac output. Nevertheless, the isovolumic measurements indicate a significant positive inotropic effect of IRL 1620. Therefore, the selective activation of ET(B) receptors causes a positive inotropic effect, which is also detectable in vivo, as the vasoconstrictor and coronary constrictor effects are less pronounced compared to activation of both ET(A) and ET(B) receptors by ET-1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:26:24