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Titolo:
ENDOTHELINS STIMULATE PHOSPHOINOSITIDE BREAKDOWN IN THE RAT SPINAL-CORD THROUGH ET(A) RECEPTORS
Autore:
POULAT P; DORLEANSJUSTE P; DECHAMPLAIN J; COUTURE R;
Indirizzi:
UNIV MONTREAL,FAC MED,DEPT PHYSIOL,CP 6128,SUCCURSALE CTR VILLE MONTREAL PQ H3C 3J7 CANADA UNIV MONTREAL,FAC MED,DEPT PHYSIOL MONTREAL PQ H3C 3J7 CANADA UNIV SHERBROOKE,SCH MED,DEPT PHARMACOL SHERBROOKE PQ J1H 5N4 CANADA
Titolo Testata:
Journal of cardiovascular pharmacology
, volume: 26, anno: 1995, supplemento:, 3
pagine: 148 - 149
SICI:
0160-2446(1995)26:<148:ESPBIT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-SITES; BRAIN; HYDROLYSIS; CELLS; SARAFOTOXIN; REGIONS;
Keywords:
ENDOTHELIN; INOSITOL PHOSPHATES; SPINAL CORD; ET(A) RECEPTORS; BQ-123; BQ-788; IRL-1620;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
P. Poulat et al., "ENDOTHELINS STIMULATE PHOSPHOINOSITIDE BREAKDOWN IN THE RAT SPINAL-CORD THROUGH ET(A) RECEPTORS", Journal of cardiovascular pharmacology, 26, 1995, pp. 148-149

Abstract

In rat spinal cord slices, endothelin-1 (ET-1) and -3 (ET-3), sarafotoxin 6e (STX-6c), and the ET(B) receptor agonist IRL-1620 produced increases of [H-3]inositol phosphate (IP) accumulation with the followingrank order of potency: ET-1 > ET-3 >> STX-6c = IRL-1620. The ET-1- and ET-3-induced IP accumulations were blocked by BQ-123, a selective ET(A) antagonist, with a similar inhibition constant (IC50 16.7 +/- 3.4 mu M and 8.0 +/- 1.6 mu M, respectively) whereas BQ-788, a selective ET(B) antagonist, was inactive. These data indicate that ET-induced IP accumulation in rat spinal cord is mediated by an ET(A) receptor. The present study is in agreement with ET(A) receptor-mediated cardiovascular changes induced by intrathecal injection of ET-1 in the conscious rat.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:09:31