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Titolo:
CELL-CYCLE PHASE-DEPENDENT CHANGES OF LOCALIZATION AND OLIGOMERIZATION STATES OF NUCLEOPHOSMIN B23/
Autore:
CHOU YH; YUNG BYM;
Indirizzi:
CHANG GUNG MED & ENGN COLL,DEPT PHARMACOL,CANC BIOCHEM LAB TAYUAN 333TAIWAN CHANG GUNG MED & ENGN COLL,DEPT PHARMACOL,CANC BIOCHEM LAB TAYUAN 333TAIWAN
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 1, volume: 217, anno: 1995,
pagine: 313 - 325
SICI:
0006-291X(1995)217:1<313:CPCOLA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOLAR PHOSPHOPROTEIN B23; RIBOSOMAL-RNA SYNTHESIS; HELA-CELLS; PHOSPHORYLATION SITE; ACTINOMYCIN-D; PROTEIN B23; TRANSLOCATION; GROWTH; IDENTIFICATION; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
Y.H. Chou e B.Y.M. Yung, "CELL-CYCLE PHASE-DEPENDENT CHANGES OF LOCALIZATION AND OLIGOMERIZATION STATES OF NUCLEOPHOSMIN B23/", Biochemical and biophysical research communications, 217(1), 1995, pp. 313-325

Abstract

Nucleophosmin ! B23, an abundant nucleolar phosphoprotein, accumulates in the nucleoplasm of cells during the stationary phase of growth orafter exposure to selected cytotoxic drugs [Chan, P.K. (1992) Exp. Cell Res. 203, 174-181]. Monomeric and hexameric forms of nucleophosmin ! B23 are present in cells [Yung, B.Y.M. and Chan, P.K. (1987) Biochim. Biophys. Acta. 925,74-82]. Using indirect immunofluorescence, here we show that there are changes in nucleophosmin / B23's cellular localizations throughout the cell cycle. The alternation of the nuclear and nucleolar localizations of nucleophosmin ! B23 is most frequently observed in cells of G(1) and G(1)/S phases. The incidence of the changes of localizations of nucleophosmin ! B23 decreases as cells enter into S and G(2) phases. In parallel, using Western blotting, the reversiblechange of oligomerization states between the hexameric and monomeric forms of nucleophosmin ! B23 is also found to occur most frequently incells of G(1) and G(1)/S phases. As cells progressed into S, G(2) andM phases, the frequency of the reversible change of hexameric and monomeric forms of nucleophosmin ! B23 decreases. These findings suggest that nucleophosmin / B23 being possibly involved in rRNA processing and transport, is highly active at G(1) and G(1)/S phases as demonstrated by the dynamic, reversible changes of localization and oligomerization states of nucleophosmin !B23. (C) 1995 Academic Press. Inc.

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Documento generato il 23/01/20 alle ore 06:27:36