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Titolo:
GENOTOXIC EFFECTS OF THE ALPHA,BETA-UNSATURATED ALDEHYDES 2-TRANS-BUTENAL, 2-TRANS-HEXENAL AND 2-TRANS, 6-CIS-NONADIENAL
Autore:
DITTBERNER U; EISENBRAND G; ZANKL H;
Indirizzi:
UNIV KAISERSLAUTERN,DEPT HUMAN BIOL & HUMAN GENET D-67663 KAISERSLAUTERN GERMANY UNIV KAISERSLAUTERN,DEPT HUMAN BIOL & HUMAN GENET D-67663 KAISERSLAUTERN GERMANY UNIV KAISERSLAUTERN,DEPT FOOD CHEM & ENVIRONM TOXICOL D-67663 KAISERSLAUTERN GERMANY
Titolo Testata:
Mutation research. Section on environmental mutagenesis and related subjects
fascicolo: 3, volume: 335, anno: 1995,
pagine: 259 - 265
SICI:
0165-1161(1995)335:3<259:GEOTAA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID-PEROXIDATION; ACROLEIN; ADDUCTS; CROTONALDEHYDE; DNA; CELLS; IDENTIFICATION; MUTAGENICITY; CHROMOSOMES; MECHANISM;
Keywords:
CROTONALDEHYDE; 2-TRANS-HEXENAL; 2-TRANS-6-CIS-NONADIENAL; MICRONUCLEI; SCE; CHROMOSOME ABERRATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
U. Dittberner et al., "GENOTOXIC EFFECTS OF THE ALPHA,BETA-UNSATURATED ALDEHYDES 2-TRANS-BUTENAL, 2-TRANS-HEXENAL AND 2-TRANS, 6-CIS-NONADIENAL", Mutation research. Section on environmental mutagenesis and related subjects, 335(3), 1995, pp. 259-265

Abstract

The genotoxic effects of the 2-alkenals crotonaldehyde, 2-trans-hexenal and 2-trans-6-cis-nonadienal were studied by cytogenetic methods, analyzing frequencies of sister-chromatid-exchanges, numerical and structural chromosome aberrations and micronucleus induction in human blood lymphocytes and cells of the permanent Namalva line. Crotonaldehyde and hexenal were tested in concentrations of 5 mu M to 250 mu M and nonadienal from 5 mu M to 70 mu M. Significant dose-related increases ofsister-chromatid-exchanges and micronuclei were found for all three compounds. Structural chromosomal aberrations were significantly increased only by crotonaldehyde, but not by hexenal and nonadienal. In contrast numerical chromosome aberrations were not induced by crotonaldehyde whereas hexenal and nonadienal were potent inducers of aneuploidy. The micronuclei were classified by using a centromere-specific DNA probe in a fluorescence in situ hybridization assay. Hexenal and nonadienal increased the percentage of centromere-positive micronuclei, nonadienal being considerably more potent than hexenal. From these results it was concluded that crotonaldehyde acts more as a clastogen whereas hexenal and nonadienal preferentially show aneugenic effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 03:35:52