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Titolo:
MUTAGENICITY OF TETRANITROAZOXYTOLUENES - A PRELIMINARY SCREENING IN SALMONELLA-TYPHIMURIUM STRAINS TA100 AND TA100NR
Autore:
SPANGGORD RJ; STEWART KR; RICCIO ES;
Indirizzi:
SRI INT,333 RAVENSWOOD AVE MENLO PK CA 94025
Titolo Testata:
Mutation research. Section on environmental mutagenesis and related subjects
fascicolo: 3, volume: 335, anno: 1995,
pagine: 207 - 211
SICI:
0165-1161(1995)335:3<207:MOT-AP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
2,4,6-TRINITROTOLUENE; NITROREDUCTASES;
Keywords:
TETRANITROAZOXYTOLUENES DERIVED FROM TNT; MUTAGENICITY IN SALMONELLA TYPHIMURIUM STRAINS TA100 AND TA100NR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Spanggord et al., "MUTAGENICITY OF TETRANITROAZOXYTOLUENES - A PRELIMINARY SCREENING IN SALMONELLA-TYPHIMURIUM STRAINS TA100 AND TA100NR", Mutation research. Section on environmental mutagenesis and related subjects, 335(3), 1995, pp. 207-211

Abstract

Tetranitroazoxytoluenes are polynitroaromatic compounds that can be produced during the microbial reduction of the explosive, 2,4,6-trinitrotoluene (TNT). The three major tetranitroazoxytoluenes were synthesized and tested in Salmonella typhimurium strains TA100 and TA100NR. Allcompounds were mutagenic in TA100 but not in TA100NR, indicating the need for nitroreductase activity to induce mutagenicity. The most active chemical was 4,4',6,6'-tetranitro-2,2'-azoxytoluene (2735 rev/mu mol) followed by 2',4,6,6'-tetranitro-2',4-azoxytoluene (929 rev/mu mol)and 2,2',6,6'-tetranitro-4,4'-azoxytoluene (320 rev/mu mol). These chemicals were more active than the aminodinitrotoluenes (298 rev/mu molfor 2-amino-3,6-dinitrotoluene and 115 rev/mu mol for 4-amino-2,6-dinitrotoluene) and only 4,4',6,6'-tetranitro-2,2'-azoxytoluene was more active than the parent compound, TNT (1022 rev/mu mol).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:10:46