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Titolo:
CEREBRAL GLUCOSE-METABOLISM, CSF 5-HIAA LEVELS, AND AGGRESSIVE-BEHAVIOR IN RHESUS-MONKEYS
Autore:
DOUDET D; HOMMER D; HIGLEY JD; ANDREASON PJ; MONEMAN R; SUOMI SJ; LINNOILA M;
Indirizzi:
NIAAA,CLIN STUDIES LAB,NIH BLDG 10,ROOM 3C103,10 CTR DR,MSC 1256 BETHESDA MD 20892 NIAAA,CLIN STUDIES LAB BETHESDA MD 20892 NIMH,CEREBRAL METAB LAB BETHESDA MD 20892 NICHHD,COMPARAT ETHOL LAB BETHESDA MD 20892
Titolo Testata:
The American journal of psychiatry
fascicolo: 12, volume: 152, anno: 1995,
pagine: 1782 - 1787
SICI:
0002-953X(1995)152:12<1782:CGC5LA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; 5-HYDROXYINDOLEACETIC ACID; RAT; SEROTONIN; INVOLVEMENT; ANESTHESIA; ETHANOL; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
D. Doudet et al., "CEREBRAL GLUCOSE-METABOLISM, CSF 5-HIAA LEVELS, AND AGGRESSIVE-BEHAVIOR IN RHESUS-MONKEYS", The American journal of psychiatry, 152(12), 1995, pp. 1782-1787

Abstract

Objective: Considerable evidence suggests that low concentrations of 5-hydroxyindoleacetic acid (5-HIAA) in CSF are associated with a history of aggressive behavior in both human and nonhuman primates. The purpose of this investigation was to examine the relationships among CSF 5-HIAA concentration, history of aggressive behavior, and cerebral glucose metabolism in a group of nonhuman primates whose CSF 5-HIAA had been sampled several times over the preceding 2 years and whose social behavior had been observed since birth. Method: The subjects were nineadult male rhesus monkeys studied under isoflurane anesthesia. Cerebral glucose utilization was measured by [F-18]fluorodeoxyglucose positron emission tomography. Aggressiveness ratings were made by a primatologist who had had frequent contact with the animals over several years. Results: There was a significant negative correlation between ratings of aggressive behavior and CSF 5-HIAA concentrations. There was alsoa negative correlation between the dose of pentobarbital required to induce anesthesia and level of CSF 5-HIAA. Moreover, there were significant negative correlations between CSF 5-HIAA levels and both whole brain glucose utilization and regional glucose utilization in the orbital-frontal cortex. Conclusions: These results suggest that both increased aggressiveness and low concentrations of CSF 5-HIAA are associatedwith higher brain glucose metabolism in rhesus monkeys tinder standardized anesthesia. Aggressive nonhuman primates with low CSF 5-HIAA concentrations may have ''innate'' tolerance toward functional gamma-aminobutyric acid A receptor agonists such as pentobarbital, isoflurane, and possibly alcohol.

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Documento generato il 09/08/20 alle ore 21:55:30