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Titolo:
CSF AND SERUM CONCENTRATIONS OF CLOZAPINE AND ITS DEMETHYL METABOLITE- A PILOT-STUDY
Autore:
NORDIN C; ALME B; BONDESSON U;
Indirizzi:
LINKOPING UNIV HOSP,DEPT PSYCHIAT S-58185 LINKOPING SWEDEN KAROLINSKA INST,HUDDINGE HOSP,DEPET CLIN NEUROSCI & FAMILY MED,PSYCHIAT SECT S-14186 HUDDINGE SWEDEN NATL VET INST,CHEM LAB S-75007 UPPSALA SWEDEN
Titolo Testata:
Psychopharmacology
fascicolo: 2, volume: 122, anno: 1995,
pagine: 104 - 107
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOPHRENIC-PATIENTS; CLINICAL-RESPONSE; PLASMA-LEVELS; SMOKING;
Keywords:
SCHIZOPHRENIA; CLOZAPINE; NORCLOZAPINE; ATMOSPHERIC PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
C. Nordin et al., "CSF AND SERUM CONCENTRATIONS OF CLOZAPINE AND ITS DEMETHYL METABOLITE- A PILOT-STUDY", Psychopharmacology, 122(2), 1995, pp. 104-107

Abstract

With the aim of exploring putative correlations between serum and CSFlevels of clozapine and its demethyl metabolite, lumbar- puncture wasperformed on four male and five female schizophrenic patients during long-term treatment with clozapine. Three consecutive 6-ml fractions were collected after at least 8 h of bedrest and fasting. On comparing serum and CSF levels, a correlation was found for norclozapine in the third (13-18 ml) CSF fraction. Norclozapine in the first (0-6 ml) CSF correlated significantly with height. The CSF/serum ratio of clozapinein the first fraction was correlated significantly with body weight. No correlations were found between serum levels of clozapine and norclozapine, or between the serum and CSF levels of clozapine. The study suffers from a small number of patients (for ethical reasons), but the present results might be explicable if the first (0-6 ml) CSF fractionrepresents a cul-du-sac of the CSF, mirroring the previous day's druglevels. The second fraction, then, will represent the CSF level in the steady state during the night.

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Documento generato il 25/01/20 alle ore 19:09:17