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Titolo:
PHARMACOKINETICS AND PHARMACODYNAMICS OF TRANS-ENDOMETRIAL ADMINISTERED PEPTIDES AND MACROMOLECULES
Autore:
HOFFMAN A; SHAKED I; AVRAMOFF A; GOLOMB G;
Indirizzi:
HEBREW UNIV JERUSALEM,SCH PHARM,DEPT PHARMACEUT,POB 12065 IL-91120 JERUSALEM ISRAEL
Titolo Testata:
Advanced drug delivery reviews
fascicolo: 2, volume: 17, anno: 1995,
pagine: 191 - 203
SICI:
0169-409X(1995)17:2<191:PAPOTA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT-HUMAN-ERYTHROPOIETIN; PULSATILE INSULIN; DELIVERY; CALCITONIN; SECRETION; PROTEINS;
Keywords:
INTRAUTERINE ADMINISTRATION; DRUG ABSORPTION; BIOAVAILABILITY; INSULIN; DEXTRAN; POLYETHYLENE GLYCOL; CALCITONIN; ERYTHROPOIETIN; INPUT FUNCTION; CONCENTRATION-EFFECT RELATIONSHIP;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A. Hoffman et al., "PHARMACOKINETICS AND PHARMACODYNAMICS OF TRANS-ENDOMETRIAL ADMINISTERED PEPTIDES AND MACROMOLECULES", Advanced drug delivery reviews, 17(2), 1995, pp. 191-203

Abstract

The pharmacokinetic considerations that are unique to the intrauterine (IU) route of macromolecule administration are discussed, and specific examples of macromolecules with high (insulin) and low (dextran 70000 and polyethylene glycol 4000) absorption rates? following IU administration in rats are addressed. The pharmacodynamic aspects of IU administration are also discussed with specific focus on the differences between the continuous mode of peptide administration in contrast to the pulsatile mode and on counter-regulation by feedback mechanisms in the body. These issues are demonstrated by specific examples of the kinetics of action of calcitonin, erythropoietin and insulin following IUadministration in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 10:07:56