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Titolo:
S-MEPHENYTOIN HYDROXYLATION PHENOTYPES IN A JORDANIAN POPULATION
Autore:
HADIDI HF; IRSHAID YM; WOOSLEY RL; IDLE JR; FLOCKHART DA;
Indirizzi:
GEORGETOWN UNIV,MED CTR,DEPT MED,DIV CLIN PHARMACOL,ROOM GM12A,PRECLIN SCI BLDG WASHINGTON DC 20007 GEORGETOWN UNIV,MED CTR,DEPT MED,DIV CLIN PHARMACOL WASHINGTON DC 20007 JORDAN UNIV SCI & TECHNOL,FAC MED,DEPT PHARMACOL IRBID JORDAN GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL WASHINGTON DC 20007 UNIV NEWCASTLE UPON TYNE,DEPT PHARMACOL SCI,PHARMACOGENET RES UNIT NEWCASTLE TYNE NE1 7RU TYNE & WEAR ENGLAND
Titolo Testata:
Clinical pharmacology and therapeutics
fascicolo: 5, volume: 58, anno: 1995,
pagine: 542 - 547
SICI:
0009-9236(1995)58:5<542:SHPIAJ>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC POLYMORPHISMS; DRUG-METABOLISM; HUMAN-LIVER; OXIDATION; SPARTEINE; PHARMACOGENETICS; DEBRISOQUINE; DEFICIENCY; DISPOSITION; OMEPRAZOLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
H.F. Hadidi et al., "S-MEPHENYTOIN HYDROXYLATION PHENOTYPES IN A JORDANIAN POPULATION", Clinical pharmacology and therapeutics, 58(5), 1995, pp. 542-547

Abstract

We tested the ability of 194 unrelated, healthy Jordanian volunteers to metabolize S-mephenytoin. Mephenytoin (100 mg) was coadministered with debrisoquin (10 mg) orally and urine was collected for 8 hours. Mephenytoin metabolism was tested according to three measures: the amount of 4-hydroxyme-phenytoin, the S/R enantiomeric ratio, and the presence of a polar, acid-labile metabolite in urine collected for 8 hours after the dose. The S/R ratio and the presence of the acid-labile metabolite were determined in the urine of 16 patients who had low amounts of 4-hydroxymephenytoin (log hydroxylation index greater than or equalto 1). On examination of these three parameters of oxidation status, nine subjects were found to be poor metabolizers of mephenytoin by allthree parameters. Thus 4.6% (95% confidence interval of 1.6% to 7.6%)of Jordanian subjects studied were poor metabolizers of mephenytoin. According to the Hardy-Weinberg Law, the frequency of the recessive autosomal gene controlling the poor metabolizer status of mephenytoin was predicted to be 0.215% (95% confidence interval of 0.146% to 0.283%). These results are on the same order of magnitude as those determinedin European white populations and constitute the first report in Arabpopulations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 04:08:56