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Titolo:
HIGH-RESOLUTION QUANTITATIVE RELAXATION AND DIFFUSION MRI OF 3 DIFFERENT EXPERIMENTAL BRAIN-TUMORS IN RAT
Autore:
EIS M; ELS T; HOEHNBERLAGE M;
Indirizzi:
MAX PLANCK INST NEUROL RES,DEPT EXPTL NEUROL,GLEUELER STR 50 D-50931 COLOGNE GERMANY MAX PLANCK INST NEUROL RES,DEPT EXPTL NEUROL D-50931 COLOGNE GERMANY
Titolo Testata:
Magnetic resonance in medicine
fascicolo: 6, volume: 34, anno: 1995,
pagine: 835 - 844
SICI:
0740-3194(1995)34:6<835:HQRADM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVOXEL INCOHERENT MOTION; NUCLEAR MAGNETIC-RESONANCE; CEREBRAL-ISCHEMIA; CONTRAST AGENT; RELAXOMETRY; ENHANCEMENT; PERFUSION; GLIOMA; CYSTS; RARE;
Keywords:
QUANTITATIVE MRI; RELAXOMETRY; APPARENT DIFFUSION COEFFICIENT; RAT BRAIN TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
M. Eis et al., "HIGH-RESOLUTION QUANTITATIVE RELAXATION AND DIFFUSION MRI OF 3 DIFFERENT EXPERIMENTAL BRAIN-TUMORS IN RAT", Magnetic resonance in medicine, 34(6), 1995, pp. 835-844

Abstract

The potential of quantitative parameter images of the relaxation times T-1 and T-2, the proton density rho and the apparent diffusion coefficient (ADC) to characterize three different experimental rat brain tumors (F98 glioma, RN6 Schwannoma, and E376 neuroblastoma) was studied,All parameter values, as determined in histologically confirmed regions of interest (ROI), were higher in edema than in tumor, which in turn were elevated with respect to normal brain, ROI values of ADC and T-2 delivered statistically significant (P < 0.01) differentiation between tumor and edema. Multidimensional parameter combinations improved differentiation between different tissues, However, the three tumor types could not be differentiated, All parameter maps allowed the identification of the whole tumor-edema area, On T-2, images, edema could be identified best, whereas the tumor itself was hardly visualized, In many cases, tumor presentation using T-1, maps corresponded best with histology, nevertheless suffering from a poor tumor-edema differentiation.

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Documento generato il 18/09/20 alle ore 17:23:57