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Titolo:
FAMILIAR PSEUDOHYPERKALEMIA EXHIBITS ENHANCED ERYTHROCYTE GLYCOLYSIS ASSOCIATED WITH INCREASED NA+ AND K+ DEPENDENT ATPASE ACTIVITY
Autore:
ENGSTROM I; NYSTROM F; WALDENSTROM A; RONQUIST G;
Indirizzi:
UNIV UPPSALA HOSP,DEPT CLIN CHEM S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT CLIN CHEM S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT INTERNAL MED S-75185 UPPSALA SWEDEN LINKOPING UNIV HOSP,DEPT ENDOCRINOL S-58185 LINKOPING SWEDEN
Titolo Testata:
Trace elements in medicine
fascicolo: 4, volume: 12, anno: 1995,
pagine: 173 - 178
SICI:
0174-7371(1995)12:4<173:FPEEEG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; PERMEABILITY;
Keywords:
PSEUDOHYPERKALEMIA; ENERGY CHARGE; ERYTHROCYTES; LACTATE; NA+- AND K+-DEPENDENT; ATPASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
I. Engstrom et al., "FAMILIAR PSEUDOHYPERKALEMIA EXHIBITS ENHANCED ERYTHROCYTE GLYCOLYSIS ASSOCIATED WITH INCREASED NA+ AND K+ DEPENDENT ATPASE ACTIVITY", Trace elements in medicine, 12(4), 1995, pp. 173-178

Abstract

Erythrocytes were isolated from 2 patients with familial pseudohyperkalemia and 7 controls for energy metabolic studies under different conditions. Incubation of erythrocytes from patients for up to 4 hours at37 degrees C revealed a pathological decrease in energy charge, EC, (43.9%) compared to controls (24.8%) p < 0.001, which could be explained by enhanced ion pumping. Further experiments were therefore conducted with ouabain in incubation medium. The EC-sparing effect in patients' erythrocytes was substantial (18.4%) compared with 7.1% in controls p < 0.01. Glucose enrichment of incubation medium revealed an enhancedlactate production at 4 hours in erythrocytes of patients with a significantly higher lactate/total nucleotide ratio, 5.4 versus 3.6 in controls, p < 0.001. SDS-PAGE did not reveal any gross alteration of membrane major proteins in erythrocytes from patients. We conclude that the metabolic derangements observed on incubation of erythrocytes from patients with familial pseudohyperkalemia are pertaining to an enhancedleakage of potassium ions out of the cells possibly combined with an increased influx of sodium ions eliciting the Na+- and K+-dependent ATPase system to work at an enhanced rate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:35:08