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Titolo:
MS-8209, A NEW AMPHOTERICIN-B DERIVATIVE, PROVIDES ENHANCED EFFICACY IN DELAYING HAMSTER SCRAPIE
Autore:
ADJOU KT; DEMAIMAY R; LASMEZAS C; DESLYS JP; SEMAN M; DORMONT D;
Indirizzi:
CEA,DEPT RECH MED,CRSSA,SERV NEUROVIROL,DSV,60-68 AVE DIV LECLERC,BP 6 F-92265 FONTENAY ROSES FRANCE UNIV PARIS 07,IMMUNODIFFERENCIAT LAB PARIS FRANCE
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 12, volume: 39, anno: 1995,
pagine: 2810 - 2812
SICI:
0066-4804(1995)39:12<2810:MANADP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPLICATION; PROTEIN; PRION; AGENT;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
K.T. Adjou et al., "MS-8209, A NEW AMPHOTERICIN-B DERIVATIVE, PROVIDES ENHANCED EFFICACY IN DELAYING HAMSTER SCRAPIE", Antimicrobial agents and chemotherapy, 39(12), 1995, pp. 2810-2812

Abstract

To test the efficacy of a new amphotericin B derivative, MS-8209, in delaying scrapie, hamsters were infected intracerebrally with the 263Kscrapie agent and treated,vith MS-8209 either early in the course of the disease or continuously, The results show that (i) all treatments lengthened the incubation period of hamster scrapie, (ii) continuous treatment with MS-8209 doubled the length of the incubation period compared with that observed in infected, untreated animals, and (iii) all treatments delayed the accumulation of a proteinase-resistant prion protein and glial fibrillary acidic protein in the brain, These findingssuggest that MS-8209 is a powerful tool for investigating the pathogenesis of transmissible subacute spongiform encephalopathies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:34:40