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Titolo:
THERAPEUTIC DRUG-MONITORING - RELEVANCE DURING THE DRUG-TREATMENT OF PSYCHIATRIC-DISORDERS
Autore:
BALANTGORGIA EA; BALANT LP;
Indirizzi:
UNIV HOSP GENEVA,DEPT PSYCHIAT,THERAPEUT DRUG MONITORING UNIT,BELLE IDEE 2,CHEM PETIT BEL AIR CH-1225 CHENEY SWITZERLAND UNIV HOSP GENEVA,DEPT PSYCHIAT,CLIN RES & CLINIMETR UNIT GENEVA SWITZERLAND
Titolo Testata:
CNS DRUGS
fascicolo: 6, volume: 4, anno: 1995,
pagine: 432 - 453
SICI:
1172-7047(1995)4:6<432:TD-RDT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2-DOPAMINE RECEPTOR OCCUPANCY; SCHIZOPHRENIC-PATIENTS; ANTIPSYCHOTIC-DRUGS; PLASMA-LEVEL; CLINICAL PHARMACOKINETICS; TRICYCLIC ANTIDEPRESSANTS; DEBRISOQUINE HYDROXYLATION; OXIDATION POLYMORPHISM; ENDOGENOUS-DEPRESSION; BLOOD-CONCENTRATIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
67
Recensione:
Indirizzi per estratti:
Citazione:
E.A. Balantgorgia e L.P. Balant, "THERAPEUTIC DRUG-MONITORING - RELEVANCE DURING THE DRUG-TREATMENT OF PSYCHIATRIC-DISORDERS", CNS DRUGS, 4(6), 1995, pp. 432-453

Abstract

This review discusses case reports of patients treated with psychotropic medications for which therapeutic drug monitoring (TDM) was found useful. The use of this approach is based on the assumption that previous papers on TDM have largely used the available database of controlled studies to establish that excessively low concentrations of antidepressants, antipsychotics or mood stabilisers often lead to poor treatment response, whereas excessively high concentrations are associated with an increased risk of unwanted side effects and even poor response for some drugs. Typical situations in which TDM has been found to be clinically useful include poor compliance, patients who are ultra-rapidor poor metabolisers, elderly patients, instances of metabolic inhibition and induction, and patients with liver dysfunction. In order to provide clinically relevant information, certain practical aspects of TDM must be respected. The results of the assays must be rapidly available to the treating physician, selection of medications to be monitored must be based on the daily practice in the given psychiatric institution, analytical methods must be specific, and numerical results should be complemented by a short written comment. Under these conditions, TDM in psychiatry is a cost-effective means to assessing compliance, enhancing therapeutic response, avoiding toxicity, increasing quality of life and improving the therapeutic alliance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 13:04:42