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Titolo:
THE EFFECT OF ENDOTHELIUM ON THE RESPONSE TO PROPOFOL ON BOVINE CORONARY-ARTERY RINGS
Autore:
GACAR N; GOK S; KALYONCU NI; OZEN I; SOYKAN N; AKTURK G;
Indirizzi:
KARADENIZ TECH UNIV,FAC MED,DEPT PHARMACOL TRABZON 61080 TURKEY KARADENIZ TECH UNIV,FAC MED,DEPT PHARMACOL TRABZON 61080 TURKEY KARADENIZ TECH UNIV,FAC MED,DEPT ANAESTHESIOL TRABZON 61080 TURKEY EGE UNIV,FAC MED,DEPT PHARMACOL IZMIR TURKEY
Titolo Testata:
Acta anaesthesiologica Scandinavica
fascicolo: 8, volume: 39, anno: 1995,
pagine: 1080 - 1083
SICI:
0001-5172(1995)39:8<1080:TEOEOT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
AORTIC SMOOTH-MUSCLE; DIHYDROPYRIDINES; THIOPENTONE; ACTIVATION; CHANNELS; AGONISTS; CELLS; DOG;
Keywords:
PROPOFOL; ENDOTHELIUM; BOVINE CORONARY ARTERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
N. Gacar et al., "THE EFFECT OF ENDOTHELIUM ON THE RESPONSE TO PROPOFOL ON BOVINE CORONARY-ARTERY RINGS", Acta anaesthesiologica Scandinavica, 39(8), 1995, pp. 1080-1083

Abstract

In this study the effect of propofol on isolated bovine coronary artery tone was studied in artery rings precontracted with PGF(2 alpha). Propofol, in concentrations of 10(-6)-10(-5) M did not change vascular smooth muscle tone, but at high concentrations (10(-4)10(-1) M) produced relaxation in rings with intact endothelium. In rings denuded of endothelium or treated with methylene blue, propofol produced relaxationat 10(-3)-10(-1) M concentrations, but there was a significant decrease in relaxation compared to endothelium intact rings. In the presenceof a calcium agonist (Bay K 8644; 10(-5) M), propofol produced constriction in rings denuded of endothelium. These results suggest that high concentrations of propofol may hale vasorelaxant effect on bovine coronary artery and that these effects may be due to actions on the endothelium and mediated by calcium channels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 07:54:00