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Titolo:
CIGARETTE-SMOKE INHALATION AFFECTS THE REPRODUCTIVE-SYSTEM OF FEMALE HAMSTERS
Autore:
MAGERS T; TALBOT P; DICARLANTONIO G; KNOLL M; DEMERS D; TSAI I; HOODBHOY T;
Indirizzi:
UNIV CALIF RIVERSIDE,DEPT BIOL RIVERSIDE CA 92521 UNIV CALIF RIVERSIDE,DEPT BIOL RIVERSIDE CA 92521
Titolo Testata:
Reproductive toxicology
fascicolo: 6, volume: 9, anno: 1995,
pagine: 513 - 525
SICI:
0890-6238(1995)9:6<513:CIATRO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
UTERINE BLOOD-FLOW; LUTEINIZING-HORMONE; EXPOSURE SYSTEMS; MENSTRUAL-CYCLE; MURINE OVARIAN; NICOTINE; RAT; BENZO(A)PYRENE; ESTRADIOL; CELLS;
Keywords:
UTERUS; CORPUS LUTEUM; OVIDUCT; CIGARETTE SMOKE; REPRODUCTION; HAMSTER; PREGNANCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
T. Magers et al., "CIGARETTE-SMOKE INHALATION AFFECTS THE REPRODUCTIVE-SYSTEM OF FEMALE HAMSTERS", Reproductive toxicology, 9(6), 1995, pp. 513-525

Abstract

The purpose of this study was to determine if inhalation of mainstream (MS) or sidestream (SS) smoke affects the reproductive organs of female hamsters. Females inhaled smoke from one or two cigarettes twice per day for 30 d prior to mating using a smoking machine equipped for nose only breathing. Serum cotinine levels were within the ranges foundin active and passive humans smokers. On day 7 of pregnancy, the reproductive organs of controls and smokers were evaluated for the total number of corpora lutea (CL), the percentage of normal, pink, and smallCL, the vascular area in the CL, the ultrastructure of the oviductal epithelium, the ratio of ciliated to secretory cells in the ampulla ofthe oviduct, the stretchability of the uterine horns, the percentage of implantation sites, and the percentage of touching implantation sites. All parameters, except the percentages of implantation sites and of small CL, were affected by exposure to smoke. To determine if the effects of smoking on the ovary and uterus could be reversed, females smoked for 30 d, remained in their cages without smoking for 30 d, and then were mated and evaluated on day 7 of pregnancy. In this reversal experiment, all ovarian and uterine parameters (except total CL) previously affected by smoking were normal in MS and SS females. These experimental observations show that components in both MS and SS smoke, when delivered at levels comparable to those human smokers receive, can affect the ovary, oviduct, and uterus.

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Documento generato il 03/12/20 alle ore 15:48:40