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Titolo:
RISPERIDONE DOES NOT ELEVATE NEUROTENSIN MESSENGER-RNA IN RAT NUCLEUS-ACCUMBENS AND CAUDATE-PUTAMEN
Autore:
MIJNSTER MJ; DOCTER GJ; VOORN P;
Indirizzi:
VRIJE UNIV AMSTERDAM,GRAD SCH NEUROSCI AMSTERDAM,NEUROSCI RES INST,DEPT ANAT & EMBRYOL 1081 BT AMSTERDAM NETHERLANDS
Titolo Testata:
NeuroReport
fascicolo: 16, volume: 6, anno: 1995,
pagine: 2209 - 2212
SICI:
0959-4965(1995)6:16<2209:RDNENM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; SCHIZOPHRENIC-PATIENTS; NEUROMEDIN-N; EXPRESSION; GENE; BRAIN;
Keywords:
HALOPERIDOL; IN SITU HYBRIDIZATION; D-2 RECEPTOR; 5-HT2 RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Mijnster et al., "RISPERIDONE DOES NOT ELEVATE NEUROTENSIN MESSENGER-RNA IN RAT NUCLEUS-ACCUMBENS AND CAUDATE-PUTAMEN", NeuroReport, 6(16), 1995, pp. 2209-2212

Abstract

THE ability of the novel antipsychotic drug risperidone to alter striatal neurotensin mRNA levels was investigated and compared with the typical antipsychotic drug haloperidol. Quantitative in situ hybridization studies revealed that risperidone treatment does not affect neurotensin mRNA levels in nucleus accumbens or caudate-putamen. This absenceof effect contrasts with the dramatic increases in neurotensin mRNA seen after haloperidol treatment in these brain regions. Our results, while conforming the atypical nature of risperidone, do not support thenotion that neurotensin elevation in the nucleus accumbens is necessary for the development of an antipsychotic effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:51:13